Evidence map›Paper›PMID 36114560›Full record

ArticleCell & bioscience2022

Super-enhancer-associated INSM2 regulates lipid metabolism by modulating mTOR signaling pathway in neuroblastoma.

Haibo Cao, Ran Zhuo, Zimu Zhang, Jianwei Wang, Yanfang Tao, Randong Yang, Xinyi Guo, Yanling Chen, Siqi Jia, Ye Yao and 14 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell & bioscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Interpreting the Function of the IL-23/IL-17 Axis through Bioinformatics.Endocrine, metabolic & immune disorders drug targets · 2025
    Review
  5. Article
  6. Metabolic reprogramming directed by super-enhancers in tumors: An emerging landscape.Molecular therapy : the journal of the American Society of Gene Therapy · 2024
    Review
  7. Article
  8. Super-enhancers complexes zoom in transcription in cancer.Journal of experimental & clinical cancer research : CR · 2023
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 1 institution in 1 country.

Haibo Cao *Institute of Pediatric Research, Children's Hospital of Soochow University, No. 92 Zhongnan Street, Suzhou, 215003, China.
Ran Zhuo *Institute of Pediatric Research, Children's Hospital of Soochow University, No. 92 Zhongnan Street, Suzhou, 215003, China.
Zimu Zhang *Institute of Pediatric Research, Children's Hospital of Soochow University, No. 92 Zhongnan Street, Suzhou, 215003, China.
Jianwei Wang *Institute of Pediatric Research, Children's Hospital of Soochow University, No. 92 Zhongnan Street, Suzhou, 215003, China.
Yanfang TaoInstitute of Pediatric Research, Children's Hospital of Soochow University, No. 92 Zhongnan Street, Suzhou, 215003, China.
Randong YangInstitute of Pediatric Research, Children's Hospital of Soochow University, No. 92 Zhongnan Street, Suzhou, 215003, China.
Xinyi GuoMedical College of Soochow University, Suzhou, Jiangsu, 215123, China.
Yanling ChenInstitute of Pediatric Research, Children's Hospital of Soochow University, No. 92 Zhongnan Street, Suzhou, 215003, China.
Siqi JiaInstitute of Pediatric Research, Children's Hospital of Soochow University, No. 92 Zhongnan Street, Suzhou, 215003, China.
Ye YaoInstitute of Pediatric Research, Children's Hospital of Soochow University, No. 92 Zhongnan Street, Suzhou, 215003, China.
Pengcheng YangInstitute of Pediatric Research, Children's Hospital of Soochow University, No. 92 Zhongnan Street, Suzhou, 215003, China.
Juanjuan YuInstitute of Pediatric Research, Children's Hospital of Soochow University, No. 92 Zhongnan Street, Suzhou, 215003, China.
Wanyan JiaoInstitute of Pediatric Research, Children's Hospital of Soochow University, No. 92 Zhongnan Street, Suzhou, 215003, China.
Xiaolu LiInstitute of Pediatric Research, Children's Hospital of Soochow University, No. 92 Zhongnan Street, Suzhou, 215003, China.
Fang FangInstitute of Pediatric Research, Children's Hospital of Soochow University, No. 92 Zhongnan Street, Suzhou, 215003, China.
Yi XieInstitute of Pediatric Research, Children's Hospital of Soochow University, No. 92 Zhongnan Street, Suzhou, 215003, China.
Gen LiInstitute of Pediatric Research, Children's Hospital of Soochow University, No. 92 Zhongnan Street, Suzhou, 215003, China.
Di WuInstitute of Pediatric Research, Children's Hospital of Soochow University, No. 92 Zhongnan Street, Suzhou, 215003, China.
Hairong WangInstitute of Pediatric Research, Children's Hospital of Soochow University, No. 92 Zhongnan Street, Suzhou, 215003, China.
Chenxi FengInstitute of Pediatric Research, Children's Hospital of Soochow University, No. 92 Zhongnan Street, Suzhou, 215003, China.
Yunyun XuInstitute of Pediatric Research, Children's Hospital of Soochow University, No. 92 Zhongnan Street, Suzhou, 215003, China.
Zhiheng LiInstitute of Pediatric Research, Children's Hospital of Soochow University, No. 92 Zhongnan Street, Suzhou, 215003, China.
Jian PanInstitute of Pediatric Research, Children's Hospital of Soochow University, No. 92 Zhongnan Street, Suzhou, 215003, China. panjian2008@163.com.ORCID http://orcid.org/0000-0002-0292-5141
Jian WangInstitute of Pediatric Research, Children's Hospital of Soochow University, No. 92 Zhongnan Street, Suzhou, 215003, China. wj196312@vip.163.com.
Soochow University · CN

Funding

Jiangsu Provincial Key Research and Development Program BE2020659National Natural Science Foundation of China 81902534National Natural Science Foundation of China 82072767Science and Technology Support Program of Jiangsu Province BE2021657Suzhou Clinical Medical Center Szlcyxzx202104Suzhou Introduced Project of Clinical Medical Expert Team SZYJTD201706the Science and Technology Project of Soochow SS2019011
6 · The paper itself

Abstract

backgroundAbnormal lipid metabolism is one of the most prominent metabolic changes in cancer. Studies have shown that lipid metabolism also plays an important role in neuroblastoma. We recently discovered that the insulinoma-associated 2 gene (INSM2) could regulate lipid metabolism in neuroblastoma (NB) and is improperly controlled by super enhancers, a mammalian genome region that has been shown to control the expression of NB cell identity genes. However, the specific molecular pathways by which INSM2 leads to NB disease development are unknown.

resultsWe identified INSM2 as a gene regulated by super enhancers in NB. In addition, INSM2 expression levels were significantly upregulated in NB and correlated with poor prognosis in patients. We found that INSM2 drives the growth of NB cell lines both in vitro and in vivo. Knocking down INSM2 inhibited fatty acid metabolism in NB cells. Mechanistically, INSM2 regulates the expression of SREBP1 by regulating the mTOR signaling pathway, which in turn affects lipid metabolism, thereby mediating the occurrence and development of neuroblastoma.

conclusionINSM2 as a super-enhancer-associated gene could regulates lipid metabolism by modulating mTOR signaling pathway in neuroblastoma.

Indexed as

INSM2Lipid metabolismmTORNeuroblastomaSREBP1Super-enhancer

Identifiers

PMID36114560
PMCPMC9482322
OpenAlexW4295997755

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.