ArticleBMC psychiatry2022
Suicide attempt rate and the risk factors in young, first-episode and drug-naïve Chinese Han patients with major depressive disorder.
Article in BMC psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Risk Factors for Suicide Attempts in Chinese Patients with Major Depressive Disorder: A Systematic Review and Meta-Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2025Pooled it
- Risk factors for perimenopausal depression in Chinese women: a meta-analysis.Frontiers in psychiatry · 2023Pooled it
- Immune-metabolic dysregulation and suicide risk in adolescents with major depressive disorder: a cross-sectional study.BMC psychiatry · 2026Article
- Factors influencing suicidal ideation in Chinese adolescents with first-episode depressive disorder: a cross-sectional study.BMC psychology · 2026Article
- Establishment and Validation of Machine Learning Model for Predicting Suicide Risk in Patients with Major Depressive Disorder.Neuropsychiatric disease and treatment · 2026Article
- Prevalence and correlates of suicide attempts in working-age, first-episode, drug-naïve major depressive disorder patients.BMC psychiatry · 2025Article
- Association between morphological and mechanical properties of lower limb muscles and metabolic syndrome in type 2 diabetes.Diabetology & metabolic syndrome · 2025Article
- A Clinical-Metabolic Prediction Model for Suicidal Behaviors Risk Stratification in First-Admission Major Depressive Disorder: A Cross-Sectional Analysis.Neuropsychiatric disease and treatment · 2025Article
- Nomogram for estimating the risk of suicide attempts in major depressive disorder: integrating demographic, clinical and biochemical markers - a cross-sectional study.Frontiers in psychiatry · 2025Article
- Effects of neuroticism on suicide risk in major depressive disorder and bipolar disorder.Frontiers in psychiatry · 2025Article
- Prevalence and risk factors of suicide attempts in young, first-episode and drug-naïve Chinese Han outpatients with psychotic major depressive disorder.European archives of psychiatry and clinical neuroscience · 2024Article
- U-shaped association between fasting blood glucose and suicide attempts in Chinese patients with first-episode drug-naïve major depressive disorder.BMC psychiatry · 2024Article
- Prevalence and risk factors for psychotic symptoms in young, first-episode and drug-naïve patients with major depressive disorder.BMC psychiatry · 2024Article
- The influence of childhood trauma and chronotype on suicide attempts in Chinese emerging adults with severe depressive symptoms.BMC psychology · 2024Article
- Prevalence and related factors of first-time suicide attempts in the past 14 days in Chinese adult patients with first-episode drug-naïve major depressive disorder.Frontiers in psychiatry · 2024Article
- (-)-Epigallocatechin gallate alleviates chronic unpredictable mild stress-induced depressive symptoms in mice by regulating the mTOR autophagy pathway and inhibiting NLRP3 inflammasome activation.Food science & nutrition · 2024Article
- Neural responses to decision-making in suicide attempters with youth major depressive disorder.NeuroImage. Clinical · 2024Article
- Sex Differences in Suicide Attempts: A Cross-Sectional Study in Patients with First-Episode and Drug-Naïve Major Depression Disorder.Depression and anxiety · 2024Article
- Development and Validation of a Prediction Model for Co-Occurring Moderate-to-Severe Anxiety Symptoms in First-Episode and Drug Naïve Patients With Major Depressive Disorder.Depression and anxiety · 2024Article
- Development and validation of a nomogram for suicide attempts in patients with first-episode drug-naïve major depressive disorder.Frontiers in psychiatry · 2024Article
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Authors and funding
17 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn recent years, the rates of suicide among young people have been increasing, and major depressive disorder (MDD) is regarded to be its main cause. Many factors such as thyroid dysfunction and metabolic abnormalities are thought to mediate this process, but the conclusions are inconsistent. This study investigated the rate of suicide attempts and associated risk factors among young, first-episode and drug-naïve Chinese Han patients with MDD.
methodsA total of 917 patients with MDD (aged 18 ~ 35 years) were recruited. Demographic and clinical data were collected and thyroid function, fasting blood glucose and lipid profiles were measured. The Hamilton Depression Rating Scale-17 items (HAMD-17), Hamilton Anxiety Rating Scale (HAMA), positive symptom subscale of Positive and Negative Syndrome Scale (PANSS) and clinical global impression of severity scale (CGI-S) were adopted to assess depression, anxiety, psychotic symptoms and disease severity respectively.
resultsThe rate of suicide attempts was 19.5% in young MDD patients. There were significant differences in age (p = 0.003), education level (p = 0.001), age of onset (p = 0.004) and disease duration (p = 0.001) between patients with and without suicide attempts. Compared with patients without suicide attempts, patients with suicide attempts had significantly higher scores on the HAMD-17, HAMA, PANSS positive symptom subscale and CGI-S (all p < 0.001). Patients with suicide attempts had significantly higher levels of TSH (p < 0.001), TgAb (p = 0.004), TPOAb (p < 0.001), TG (p = 0.016), TC (p < 0.001), LDL (p < 0.001), and fasting glucose (p < 0.001), but significantly lower levels of HDL (p < 0.001). Logistic regression analysis showed that marital status (OR = 0.515, 95%CI: 0.280-0.950, p = 0.515), disease duration (OR = 1.100, 95%CI: 1.013-1.194, p = 0.024), HAMA score (OR = 1.313, 95%CI: 1.205-1.430, p < 0.001), CGI-S score (OR = 1.875, 95%CI: 1.339-2.624, p < 0.001), levels of FT3(OR = 0.717, 95%CI: 0.536-0.959, p = 0.025), TPOAb (OR = 1.004, 95%CI: 1.002-1.006, p < 0.001), TC (OR = 1.330, 95%CI: 1.011-1.750, p = 0.042) and LDL (OR = 0.736, 95%CI: 0.558-0.971, p = 0.030) were all independently associated with suicide attempts in young MDD patients.
conclusionsIn China, the rate of suicide attempts in young patients with MDD is quite high and thyroid dysfunction and metabolic abnormalities may be implicated in its pathogenesis.
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