ArticleCommunications biology2022
Inhibition of the medial amygdala disrupts escalated aggression in lactating female mice after repeated exposure to male intruders.
Article in Communications biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 11 citations in OpenAlex.
- The hormonal and neural control of maternal aggression.Current opinion in neurobiology · 2026Review
- Familiarity Gates Socially Transmitted Aggression via the Medial Amygdala.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- CART Neurons in the Hypothalamic Ventral Premammillary Nucleus (PMv) in Rats Mediate Maternal, But Not Inter-male Aggression.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Article
- Development of catecholaminergic neurons of Otp-lineage in the medial extended amygdala and related forebrain centers.Frontiers in neuroanatomy · 2025Article
- Aggression Unleashed: Neural Circuits from Scent to Brain.Brain sciences · 2024Review
- The vomeronasal system of the wolf (Canis lupus signatus): The singularities of a wild canid.Journal of anatomy · 2024Article
- Editorial: Long-lasting neurobehavioral effects of early-life events.Frontiers in neuroscience · 2024Article
- Neurobiology of Aggression-Review of Recent Findings and Relationship with Alcohol and Trauma.Biology · 2023Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Virgin female laboratory mice readily express pup care when co-housed with dams and pups. However, pup-sensitized virgins fail to express intruder-directed aggression on a single session of testing. To study whether repeated testing would affect the onset and dynamics of maternal or intruder-directed aggression, we tested dams and their accompanying virgins from postpartum day 4 to 6. Repeated testing led to escalated aggression towards male intruders in dams, but virgins never developed aggression. In dams, inhibition of the medial amygdala using DREADD (designer receptors exclusively activated by designer drugs) vectors carrying the hM4Di receptor blocked the expected increase in maternal aggression on the second testing day. Our data support that the onset of maternal aggression is linked to physiological changes occurring during motherhood, and that medial amygdala, a key centre integrating vomeronasal, olfactory and hormonal information, enables the expression of escalated aggression induced by repeated testing. Future studies selectively targeting specific neuronal populations of the medial amygdala are needed to allow a deeper understanding of the control of experience-dependent aggression increase, a phenomenon leading to the high aggression levels found in violent behaviours.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.