ArticleNature communications2022
Efficient and accurate frailty model approach for genome-wide survival association analysis in large-scale biobanks.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Genetic architecture of lumbar spinal stenosis.Nature communications · 2026Pooled it
- Inframe insertion and splice site variants in MFGE8 associate with protection against coronary atherosclerosis.Communications biology · 2022Pooled it
- Can Psychiatric Genetics Advance Without Incorporating a Life Course Perspective?Biological psychiatry · 2026Review
- Scalable and accurate rare-variant association tests for whole genome sequencing time-to-event analysis in large biobanks.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Dimension Reduction for Large-Scale Federated Data: Statistical Rate and Asymptotic Inference.Journal of the American Statistical Association · 2026Article
- Improving accuracy in genome-wide association studies: a two-step approach for handling below limit of detection biomarker measurements.NAR genomics and bioinformatics · 2025Article
- SPAmix: a scalable, accurate, and universal analysis framework for large-scale genetic association studies in admixed populations.Genome biology · 2025Article
- Limited overlap between genetic effects on disease susceptibility and disease survival.Nature genetics · 2025Article
- BAYESIAN VARIABLE SELECTION IN A COX PROPORTIONAL HAZARDS MODEL WITH THE "SUM OF SINGLE EFFECTS" PRIOR.ArXiv · 2025Article
- Efficient and accurate framework for genome-wide gene-environment interaction analysis in large-scale biobanks.Nature communications · 2025Article
- Distinct explanations underlie gene-environment interactions in the UK Biobank.American journal of human genetics · 2025Article
- SPANature communications · 2025Article
- Analysis of follow-up data in large biobank cohorts: a review of methodology.Frontiers in genetics · 2025Article
- Quantifying variant contributions in cystic kidney disease using national-scale whole-genome sequencing.The Journal of clinical investigation · 2024Article
- Fast and scalable ensemble learning method for versatile polygenic risk prediction.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Multi-organ imaging-derived polygenic indexes for brain and body health.medRxiv : the preprint server for health sciences · 2024Article
- A multi-ancestry genome-wide association study in type 1 diabetes.Human molecular genetics · 2024Article
- Distinct explanations underlie gene-environment interactions in the UK Biobank.medRxiv : the preprint server for health sciences · 2024Article
- Fitting the Cox proportional hazards model to big data.Biometrics · 2024Article
- ADuLT: An efficient and robust time-to-event GWAS.Nature communications · 2023Article
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 3 countries.
Funding
Abstract
With decades of electronic health records linked to genetic data, large biobanks provide unprecedented opportunities for systematically understanding the genetics of the natural history of complex diseases. Genome-wide survival association analysis can identify genetic variants associated with ages of onset, disease progression and lifespan. We propose an efficient and accurate frailty model approach for genome-wide survival association analysis of censored time-to-event (TTE) phenotypes by accounting for both population structure and relatedness. Our method utilizes state-of-the-art optimization strategies to reduce the computational cost. The saddlepoint approximation is used to allow for analysis of heavily censored phenotypes (>90%) and low frequency variants (down to minor allele count 20). We demonstrate the performance of our method through extensive simulation studies and analysis of five TTE phenotypes, including lifespan, with heavy censoring rates (90.9% to 99.8%) on ~400,000 UK Biobank participants with white British ancestry and ~180,000 individuals in FinnGen. We further analyzed 871 TTE phenotypes in the UK Biobank and presented the genome-wide scale phenome-wide association results with the PheWeb browser.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.