ArticleNature communications2022
A temporal sequence of thalamic activity unfolds at transitions in behavioral arousal state.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 2 of them syntheses that pooled it.
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Who cites it
53 citing papers in PubMed, 2 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Thalamus and consciousness: a systematic review on thalamic nuclei associated with consciousness.Frontiers in neurology · 2025Pooled it
- Characteristics of macroscopic sleep structure in patients with mild cognitive impairment: a systematic review.Frontiers in psychiatry · 2023Pooled it
- Evolution and Reorganization of the Hierarchical Brain-wide Neuronal Network Through Anesthesia.Neuroscience bulletin · 2026Article
- The Central Medial Thalamus Serves as a Critical Hub for Preserved Arousability During Dexmedetomidine Sedation.Neuroscience bulletin · 2026Article
- Effects of pulvinar and combined pulvinar/anterior thalamic deep-brain stimulation on sleep: preliminary results.Journal of neurology · 2026Article
- Article
- Pupil size is linked to opposite signal fluctuations between cortical BOLD and ventricular CSF.NeuroImage · 2026Article
- Cortex-specific inversion of visual responses during sleep.Nature communications · 2026Article
- Brain-wide arousal signals are segregated from movement planning in the superior colliculus of the macaque.eLife · 2026Article
- Thalamic interictal epileptic and non-epileptic events during NREM sleep in patients with focal epilepsy: a Stereo-EEG study.EBioMedicine · 2026Article
- A hypothalamic-brainstem activity sequence underlies arousal fluctuations during daytime drowsiness.bioRxiv : the preprint server for biology · 2026Article
- Network-nodal tACS induces right-lateralization of thalamocortical connectivity.Scientific reports · 2026Article
- Cortex-specific inversion of visual responses during sleep.bioRxiv : the preprint server for biology · 2026Article
- Human brain zero: uncovering the lowest neural state for consciousness engineering.Frontiers in neuroscience · 2026Article
- Brain network dynamics in the wake-sleep transition reorganize according to task engagement.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- A thalamic perspective of (un)consciousness in pharmacological and pathological states in humans.Brain communications · 2026Article
- RHO GTPase by L1 GABAergic neurons in frontal cortex and L6 glutamatergic neurons in prefrontal cortex differentiates states of unconsciousness.Scientific reports · 2025Article
- Sleep neuroimaging: Review and future directions.Journal of sleep research · 2025Review
- Brainwide blood volume reflects opposing neural populations.bioRxiv : the preprint server for biology · 2025Article
- Subcortical Hubs of Brain Networks Sustaining Human Consciousness.Human brain mapping · 2025Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Awakening from sleep reflects a profound transformation in neural activity and behavior. The thalamus is a key controller of arousal state, but whether its diverse nuclei exhibit coordinated or distinct activity at transitions in behavioral arousal state is unknown. Using fast fMRI at ultra-high field (7 Tesla), we measured sub-second activity across thalamocortical networks and within nine thalamic nuclei to delineate these dynamics during spontaneous transitions in behavioral arousal state. We discovered a stereotyped sequence of activity across thalamic nuclei and cingulate cortex that preceded behavioral arousal after a period of inactivity, followed by widespread deactivation. These thalamic dynamics were linked to whether participants subsequently fell back into unresponsiveness, with unified thalamic activation reflecting maintenance of behavior. These results provide an outline of the complex interactions across thalamocortical circuits that orchestrate behavioral arousal state transitions, and additionally, demonstrate that fast fMRI can resolve sub-second subcortical dynamics in the human brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.