Evidence map›Paper›PMID 36113955›Full record

Observational studyThe British journal of ophthalmology2023

Risk factors associated with abandonment of care in retinoblastoma: analysis of 692 patients from 10 countries.

Thamanna Nishath, Xiudi Li, Arthika Chandramohan, Megan Othus, Xunda Ji, Yihua Zou, Sadia Sultana, Riffat Rashid, Sadik Taju Sherief, Nathalie Cassoux and 26 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in The British journal of ophthalmology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

36 authors.

Thamanna NishathDepartment of Ophthalmology, University of Washington, Seattle, Washington, USA tnishath@uw.edu.ORCID 0000-0002-7847-8691
Xiudi LiDepartment of Biostatistics, University of Washington, Seattle, Washington, USA.
Arthika ChandramohanDivision of Ophthalmology, Seattle Children's Hospital, Seattle, Washington, USA.
Megan OthusDepartment of Biostatistics, University of Washington, Seattle, Washington, USA.
Xunda JiDepartment of Ophthalmology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Yang Pu Qu, Shanghai, China.
Yihua ZouDepartment of Ophthalmology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Yang Pu Qu, Shanghai, China.
Sadia SultanaDepartment of Oculoplasty and Ocular Oncology, Ispahani Islamia Eye Institute and Hospital, Dhaka, Bangladesh.
Riffat RashidDepartment of Oculoplasty and Ocular Oncology, Ispahani Islamia Eye Institute and Hospital, Dhaka, Bangladesh.
Sadik Taju SheriefDepartment of Ophthalmology, Addis Ababa University, Addis Ababa, Ethiopia.ORCID 0000-0003-4614-4563
Nathalie CassouxDepartment of Ophthalmology, Institut Curie, Universite de Paris UFR de Medecine de Paris Centre, Paris, France.
Juan Luis Garcia LeonAnglo-American Clinic, Lima, Peru.
Rosdali Díaz CoronadoInstituto Nacional de Enfermedades Neoplasicas, Lima, Peru.
Arturo Manuel Zapata LópezInstituto Nacional de Enfermedades Neoplasicas, Lima, Peru.
Tatiana L UshakovaHead and Neck Tumors, SRI of Pediatric Oncology and Hematology of NN Blokhin National Medical Research Center Oncology of Russian Federation, Moscow, Russian Federation.
Vladimir G PolyakovHead and Neck Tumors Department, SRI of Pediatric Oncology and Hematology of NN Blokhin National Medical Research Center Oncology of Russian Federation, Moscow, Russian Federation.
Soma Rani RoyChittagong Eye Infirmary and Training Complex, Chittagong, Bangladesh.ORCID 0000-0002-7095-4489
Alia AhmadThe Children's Hospital and the Institute of Child Health, Lahore, Pakistan.
Ashwin ReddyOphthalmology, Barts Health NHS Trust, London, UK.
Mandeep S SagooOphthalmology, Barts Health NHS Trust, London, UK.
Lamis Al HarbyOcular Oncology, Moorfields Eye Hospital NHS Foundation Trust, London, UK.ORCID 0000-0001-9367-8395
Jonathan W KimUSC Roski Eye Institute, University of Southern California Keck School of Medicine, Los Angeles, California, USA.
Jesse L BerryUSC Roski Eye Institute, University of Southern California Keck School of Medicine, Los Angeles, California, USA.ORCID 0000-0002-8907-9100
Ashley PolskiUSC Roski Eye Institute, University of Southern California Keck School of Medicine, Los Angeles, California, USA.
Nick AstburyInternational Centre for Eye Health, London School of Hygiene and Tropical Medicine, London, UK.ORCID 0000-0002-8123-4823
Cova BascaranInternational Centre for Eye Health, London School of Hygiene and Tropical Medicine, London, UK.
Sharon BlumThe Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, Israel.
Richard BowmanInternational Centre for Eye Health, London School of Hygiene and Tropical Medicine, London, UK.ORCID 0000-0001-5422-4104
Matthew J BurtonClinical Research Department, London School of Hygiene and Tropical Medicine, London, UK.ORCID 0000-0003-1872-9169
Allen FosterClinical Research Department, Faculty of Infectious and Tropical Diseases, and International Centre for Eye Health, London School of Hygiene and Tropical Medicine, London, UK.
Nir GomelSheba Medical Center at Tel Hashomer, Tel Hashomer, Israel.ORCID 0000-0002-4771-1374
Naama Keren-FroimThe Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, Israel.
Shiran MadgarOphthalmology, Sheba Medical Center at Tel Hashomer, Tel Hashomer, Israel.
Marcia ZondervanInternational Centre for Eye Health, London School of Hygiene and Tropical Medicine, London, UK.
Swathi KalikiThe Operation Eyesight Universal Institute for Eye Cancer, LV Prasad Eye Institute, Hyderabad, Telangana, India.ORCID 0000-0002-0800-9961
Ido Didi FabianInternational Centre for Eye Health, London School of Hygiene and Tropical Medicine, London, UK.ORCID 0000-0002-0846-5131
Andrew StaceyDepartment of Ophthalmology, University of Washington, Seattle, Washington, USA.ORCID 0000-0002-4441-6302

Funding

Development of a surrogate liquid biopsy from the aqueous humor in retinoblastoma eyes.K08CA232344 · NCI · CHILDREN'S HOSPITAL OF LOS ANGELES · PI BERRY, JESSE L · 2018 to 2022
$1.1M
NCI NIH HHS K08 CA232344
6 · The paper itself

Abstract

backgroundRates of care abandonment for retinoblastoma (RB) demonstrate significant geographical variation; however, other variables that place a patient at risk of abandoning care remain unclear. This study aims to identify the risk factors for care abandonment across a multinational set of patients.

methodsA prospective, observational study of 692 patients from 11 RB centres in 10 countries was conducted from 1 January 2019 to 31 December 2019. Multivariate logistic regression was used to identify risk factors associated with higher rates of care abandonment.

resultsLogistic regression showed a higher risk of abandoning care based on country (high-risk countries include Bangladesh (OR=18.1), Pakistan (OR=45.5) and Peru (OR=9.23), p<0.001), female sex (OR=2.39, p=0.013) and advanced clinical stage (OR=4.22, p<0.001). Enucleation as primary treatment was not associated with a higher risk of care abandonment (OR=0.59, p=0.206).

conclusionCountry, advanced disease and female sex were all associated with higher rates of abandonment. In this analysis, enucleation as the primary treatment was not associated with abandonment. Further research investigating cultural barriers can enable the building of targeted retention strategies unique to each country.

Indexed as

Retinal NeoplasmsRetinoblastomaFemaleHumansProspective StudiesRetrospective StudiesRisk FactorsTreatment RefusalChild health (paediatrics)EpidemiologyNeoplasiaPublic healthRetina

Identifiers

PMID36113955
PMCPMC10017370

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.