ArticleNeuroImage2022
The vagus nerve mediates the stomach-brain coherence in rats.
Article in NeuroImage, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- The Impact of Alpha-Neurofeedback Training on Gastric Slow Wave Activity and Heart Rate Variability in Humans.Neurogastroenterology and motility · 2025Trial
- Gastroparesis Phenotyping: Current Methods and Emerging Opportunities With Magnetic Resonance Imaging.Neurogastroenterology and motility · 2026Review
- Whole-brain, all-optical interrogation of neuronal dynamics underlying gut and vascular interoception in zebrafish.Nature communications · 2026Article
- Interoception network in the rat brain.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- A compartmental model for simulating the gut-brain axis in gastric function regulation.Frontiers in physiology · 2026Article
- Magnetic Resonance Imaging of Gastric Motility in Conscious Rats.Neurogastroenterology and motility · 2026Article
- Review
- Cardiac, respiratory, and gastric rhythms independently modulate motor corticospinal excitability in humans.PLoS biology · 2025Article
- Sleep links hippocampal propensity for epileptiform activity to its viscerosensory inputs.Frontiers in neuroscience · 2025Article
- A neural signature for gastrointestinal symptoms in depression: insula-gastric connectivity predicts symptom severity.Frontiers in psychiatry · 2025Article
- The Microbiota-Gut-Brain Axis: Key Mechanisms Driving Glymphopathy and Cerebral Small Vessel Disease.Life (Basel, Switzerland) · 2024Review
- Interoceptive rhythms in the brain.Nature neuroscience · 2023Review
- Reliability and validity of brain-gastric phase synchronization.Human brain mapping · 2023Article
- Neurophysiology of Brain Networks Underlies Symptoms of Parkinson's Disease: A Basis for Diagnosis and Management.Diagnostics (Basel, Switzerland) · 2023Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Interactions between the brain and the stomach shape both cognitive and digestive functions. Recent human studies report spontaneous synchronization between brain activity and gastric slow waves in the resting state. However, this finding has not been replicated in any animal models. The neural pathways underlying this apparent stomach-brain synchrony is also unclear. Here, we performed functional magnetic resonance imaging while simultaneously recording body-surface gastric slow waves from anesthetized rats in the fasted vs. postprandial conditions and performed a bilateral cervical vagotomy to assess the role of the vagus nerve. The coherence between brain fMRI signals and gastric slow waves was found in a distributed "gastric network", including subcortical and cortical regions in the sensory, motor, and limbic systems. The stomach-brain coherence was largely reduced by the bilateral vagotomy and was different between the fasted and fed states. These findings suggest that the vagus nerve mediates the spontaneous coherence between brain activity and gastric slow waves, which is likely a signature of real-time stomach-brain interactions. However, its functional significance remains to be established.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.