Evidence map›Paper›PMID 36113683›Full record

ArticleToxicon : official journal of the International Society on Toxinology2022

Vasoconstrictor and hemodynamic effects of a methanolic extract from Rhinella marina toad poison.

Cintia Vieira Dos Santos, Jacqueline Kerkhoff, Caroline Aparecida Tomazelli, Camilla Ferreira Wenceslau, Adilson Paulo Sinhorin, Domingos de Jesus Rodrigues, Fernando Silva Carneiro, Gisele Facholi Bomfim

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicon : official journal of the International Society on Toxinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Cintia Vieira Dos SantosNUPADS - Health Education and Research Center, Institute of Health Sciences, Federal University of Mato Grosso, 78550-728, Sinop, MT, Brazil; Department of Pharmacology, Ribeirao Preto Medical School, University of São Paulo, 14049-900, Ribeirão Preto, SP, Brazil.
Jacqueline KerkhoffInstitute of Natural, Humanities and Social Sciences, Federal University of Mato Grosso, 78577-267, Sinop, MT, Brazil.
Caroline Aparecida TomazelliDepartment of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, 05508-000, São Paulo, SP, Brazil.
Camilla Ferreira WenceslauCardiovascular Translational Research Center, Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, SC, 29209, USA.
Adilson Paulo SinhorinInstitute of Natural, Humanities and Social Sciences, Federal University of Mato Grosso, 78577-267, Sinop, MT, Brazil.
Domingos de Jesus RodriguesInstitute of Natural, Humanities and Social Sciences, Federal University of Mato Grosso, 78577-267, Sinop, MT, Brazil.
Fernando Silva CarneiroDepartment of Pharmacology, Ribeirao Preto Medical School, University of São Paulo, 14049-900, Ribeirão Preto, SP, Brazil.
Gisele Facholi BomfimNUPADS - Health Education and Research Center, Institute of Health Sciences, Federal University of Mato Grosso, 78550-728, Sinop, MT, Brazil. Electronic address: gisele.bomfim@ufmt.br.
Universidade Federal de Mato Grosso · BRUniversidade de São Paulo · BRUniversity of South Carolina · US

Funding

Formyl peptide receptor activation induces vascular plasticity and remodeling inhypertensionR01HL149762 · NHLBI · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI WENCESLAU, CAMILLA FERREIRA · 2021 to 2025
$1.9M
Intrarenal Arteries Sense N-formyl Peptides Leading to Vascular Injury in SepsisR00GM118885 · NIGMS · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI WENCESLAU, CAMILLA FERREIRA · 2019 to 2021
$746k
NHLBI NIH HHS R01 HL149762NIGMS NIH HHS R00 GM118885
6 · The paper itself

Abstract

Rhinella marina toad is abundant in Brazil. Its poison contains cardiac glycosides called bufadienolides, which are extensively investigated for their bioactivity. Our aim was to characterize the vasoactivity of Rhinella marina poison (RmP) on the aorta of male Wistar rats. For this, the RmP was first collected and processed to obtain an alcoholic extract. To determine cardiovascular effects of RmP, we performed in vivo tests by administering RmP intravenously in doses of 0.1-0.8 mg/kg. Vascular reactivity was also performed through concentration-response curves to RmP (10 ng/mL to 200 μg/mL) in aortic segments with and without endothelium. RmP induced a concentration-dependent contraction in rat aorta which was partly endothelium-mediated. Nitric oxide contributes with this response in view that incubation with L-NAME increased the contractile response. Additionally, treatment with indomethacin [cyclooxygenase, (COX) inhibitor], nifedipine (L-type voltage-gated calcium channels blocker), and BQ-123 (ET

Indexed as

BufanolidesPoisonsAdenosine TriphosphatasesAdrenergic AgentsAdrenergic AntagonistsAnimalsBufo marinusCalcium ChannelsEndothelium, VascularHemodynamicsIndomethacinKetanserinMaleMethanolNADPH OxidasesNG-Nitroarginine Methyl EsterAdenosine TriphosphatasesAdrenergic AgentsAdrenergic AntagonistsBufanolidesCalcium ChannelsIndomethacinKetanserinMethanolNADPH OxidasesNG-Nitroarginine Methyl EsterNifedipineNitric OxidePoisonsPrazosinProstaglandin-Endoperoxide SynthasesSerotoninVasoconstrictor AgentsAmphibian poisonsAortablood pressureRhinella marinaVascular reactivity

Identifiers

PMID36113683
PMCPMC9832923
OpenAlexW4296165112

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.