Evidence map›Paper›PMID 36113473›Full record

ArticleNeuron2022

Automated optimization of TMS coil placement for personalized functional network engagement.

Charles J Lynch, Immanuel G Elbau, Tommy H Ng, Danielle Wolk, Shasha Zhu, Aliza Ayaz, Jonathan D Power, Benjamin Zebley, Faith M Gunning, Conor Liston

2 registry-linked trialsOpen access · bronzeAbstract read
In one paragraph

Article in Neuron, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 62 papers.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed
14.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05598450 naunknown statusnot on this mapstarted 2023, after this paper: background citation

rTMS for Auditory Hallucinations Guided by Magnetoencephalography

TypeinterventionalSponsorShanghai Mental Health CenterRan2023 to 2025Enrolled60ConditionsSchizophreniaArmsrTMS and MEG for auditory hallucinations via self controlled clinical trials
NCT06802939 narecruitingnot on this mapstarted 2025, after this paper: background citation

RTMS for Refractory Auditory Hallucinations Based on Personalized Targets Using Magnetoencephalography

TypeinterventionalSponsorShanghai Mental Health CenterRan2025 to 2026Enrolled36ConditionsRefractory Auditory Hallucinations, SchizophreniaArmsrTMS
3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 110 citations in OpenAlex.

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  8. Targeting mechanisms of change as a path to precision psychotherapy for community settings.Psychotherapy research : journal of the Society for Psychotherapy Research · 2026
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2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Charles J LynchDepartment of Psychiatry, Weill Cornell Medicine, 413 East 69th Street, Box 204, New York, NY 10021, USA. Electronic address: cjl2007@med.cornell.edu.
Immanuel G ElbauDepartment of Psychiatry, Weill Cornell Medicine, 413 East 69th Street, Box 204, New York, NY 10021, USA.
Tommy H NgDepartment of Psychiatry, Weill Cornell Medicine, 413 East 69th Street, Box 204, New York, NY 10021, USA.
Danielle WolkDepartment of Psychiatry, Weill Cornell Medicine, 413 East 69th Street, Box 204, New York, NY 10021, USA.
Shasha ZhuDepartment of Psychiatry, Weill Cornell Medicine, 413 East 69th Street, Box 204, New York, NY 10021, USA.
Aliza AyazDepartment of Psychiatry, Weill Cornell Medicine, 413 East 69th Street, Box 204, New York, NY 10021, USA.
Jonathan D PowerDepartment of Psychiatry, Weill Cornell Medicine, 413 East 69th Street, Box 204, New York, NY 10021, USA.
Benjamin ZebleyDepartment of Psychiatry, Weill Cornell Medicine, 413 East 69th Street, Box 204, New York, NY 10021, USA.
Faith M GunningDepartment of Psychiatry, Weill Cornell Medicine, 413 East 69th Street, Box 204, New York, NY 10021, USA.
Conor ListonDepartment of Psychiatry, Weill Cornell Medicine, 413 East 69th Street, Box 204, New York, NY 10021, USA. Electronic address: col2004@med.cornell.edu.
Weill Cornell Medicine · USCornell University · US

Funding

Efficacy of biomarker-guided rTMS for treatment resistant depressionR01MH118388 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI BHATI, MAHENDRA T, GUNNING, FAITH M · 2019 to 2025
$6.2M
Atherosclerosis in cocaine addiction: imaging risk with PET/MRR01DA049547 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Nelly Alia-Klein, Zahi A. Fayad · 2022 to 2026
$3.9M
Diagnostic and prognostic biomarkers for subtypes of addiction-related circuit dysfunctionR01DA047851 · NIDA · WEILL MEDICAL COLL OF CORNELL UNIV · PI GOLDSTEIN, RITA Z, LISTON, CONOR M · 2019 to 2022
$2.4M
Diagnostic Neuroimaging Biomarkers of Dysfunctional Valence Systems in Depression and AnxietyR56MH114976 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI GUNNING, FAITH M, LISTON, CONOR M · 2018 to 2018
$724k
Targeting salience network dysfunction in depression with individualized brain network mapping and TMSF32MH120989 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI LYNCH, CHARLES JOSEPH · 2019 to 2021
$194k
NIDA NIH HHS R01 DA047851NIDA NIH HHS R01 DA049547NIMH NIH HHS F32 MH120989NIMH NIH HHS R01 MH118388NIMH NIH HHS R56 MH114976
6 · The paper itself

Abstract

Transcranial magnetic stimulation (TMS) is used to treat multiple psychiatric and neurological conditions by manipulating activity in particular brain networks and circuits, but individual responses are highly variable. In clinical settings, TMS coil placement is typically based on either group average functional maps or scalp heuristics. Here, we found that this approach can inadvertently target different functional networks in depressed patients due to variability in their functional brain organization. More precise TMS targeting should be feasible by accounting for each patient's unique functional neuroanatomy. To this end, we developed a targeting approach, termed targeted functional network stimulation (TANS). The TANS approach improved stimulation specificity in silico in 8 highly sampled patients with depression and 6 healthy individuals and in vivo when targeting somatomotor functional networks representing the upper and lower limbs. Code for implementing TANS and an example dataset are provided as a resource.

Indexed as

Brain MappingTranscranial Magnetic StimulationBrainHeadHumansMagnetic Resonance Imagingelectric field modelingfunctional brain networksprecision functional mappingtranscranial magnetic stimulation

Identifiers

PMID36113473
PMCPMC11446252
OpenAlexW4295921799

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.