Evidence map›Paper›PMID 36113467›Full record

ReviewCell2022

Epstein-Barr virus: Biology and clinical disease.

Blossom Damania, Shannon C Kenney, Nancy Raab-Traub

Open access · greenAbstract readReview
In one paragraph

Review in Cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 385 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
385citing papers in PubMed, 2 pooled it
47.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

385 citing papers in PubMed, 2 syntheses or guidelines pooled it, 496 citations in OpenAlex.

  1. Pooled it
  2. Rash associated with antibiotic administration in patients with infectious mononucleosis: a systematic review and meta-analysis.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025
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325 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Blossom DamaniaLineberger Comprehensive Cancer Center and Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: damania@med.unc.edu.
Shannon C KenneyDepartment of Oncology, McArdle Laboratory for Cancer Research, and Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
Nancy Raab-TraubLineberger Comprehensive Cancer Center and Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
University of North Carolina at Chapel Hill · USUniversity of Wisconsin–Madison · US

Funding

Visualizing EBV and HCMV DNA Dynamics During InfectionP01CA022443 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Nathan M Sherer · 1985 to 2026
$53.1M
Vironomics and Biostatistics CoreP01CA019014 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Dirk P Dittmer · 1985 to 2026
$43.8M
The road to recovery: An assessment of patient-reported quality of life among cancer survivors in Malawi.U54CA254564 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAMANIA, BLOSSOM A · 2020 to 2024
$6.1M
Targeted Therapies for HIV-Associated Kaposi Sarcoma and LymphomaR01CA163217 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BLOSSOM A DAMANIA, Dirk P Dittmer · 2011 to 2026
$5.5M
Mechanisms of KSHV TransmissionR01CA239583 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAMANIA, BLOSSOM A, DITTMER, DIRK P · 2019 to 2023
$2.8M
Effects of EBV Type on Viral ReactivationR01AI147060 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI KENNEY, SHANNON CELESTE · 2019 to 2023
$2.6M
Role of EBV Lytic Infection in Viral TumorigenesisR01CA229673 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI KENNEY, SHANNON CELESTE · 2019 to 2023
$2.5M
Modulation of Innate Immunity by KSHVR01DE028211 · NIDCR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAMANIA, BLOSSOM A · 2018 to 2022
$2.1M
Impact of HIV on the Tumor MicroenvironmentR01CA228172 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAMANIA, BLOSSOM A, DITTMER, DIRK P · 2018 to 2022
$2.0M
EBV LMP1/LMP2A Proteins Promote Hodgkin-like Lymphomas in Humanized MiceR01CA232616 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI KENNEY, SHANNON CELESTE · 2018 to 2022
$1.9M
NCI NIH HHS P01 CA019014NCI NIH HHS P01 CA022443NCI NIH HHS R01 CA163217NCI NIH HHS R01 CA228172NCI NIH HHS R01 CA229673NCI NIH HHS R01 CA232616NCI NIH HHS R01 CA239583NCI NIH HHS U54 CA254564NIAID NIH HHS R01 AI147060NIDCR NIH HHS R01 DE028211
6 · The paper itself

Abstract

Epstein-Barr virus (EBV) is a ubiquitous, oncogenic virus that is associated with a number of different human malignancies as well as autoimmune disorders. The expression of EBV viral proteins and non-coding RNAs contribute to EBV-mediated disease pathologies. The virus establishes life-long latency in the human host and is adept at evading host innate and adaptive immune responses. In this review, we discuss the life cycle of EBV, the various functions of EBV-encoded proteins and RNAs, the ability of the virus to activate and evade immune responses, as well as the neoplastic and autoimmune diseases that are associated with EBV infection in the human population.

Indexed as

Epstein-Barr Virus InfectionsHerpesvirus 4, HumanBiologyHumansRNAViral ProteinsVirus LatencyRNAViral Proteins

Identifiers

PMID36113467
PMCPMC9529843
OpenAlexW4295921243

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.