Observational studyJournal of stroke and cerebrovascular diseases : the official journal of National Stroke Association2022
Incidence and risk factors for stroke in patients with COVID-19 in the Philippines: An analysis of 10,881 cases.
Observational study in Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 18 citations in OpenAlex.
- Impact on Transmissibility and Case Fatality Rate of COVID-19 of the Mandatory Face Shield Use in Addition to Mask during the Pandemic: The Philippine Experience.Acta medica Philippina · 2025Article
- Cross-sectional Cranial CT Imaging Findings and Patterns in Clinically Diagnosed COVID-19 Cases in a Tertiary Referral Center.Acta medica Philippina · 2025Article
- A scoping review of stroke services within the Philippines.BMC health services research · 2024Article
- Degree of COVID-19 severity and mortality in stroke: correlation of clinical and laboratory parameters.BMC neuroscience · 2024Article
- Outcomes of patients with COVID-19 and coronary artery disease and heart failure: findings from the Philippine CORONA study.BMC research notes · 2024Article
- Clinical outcomes in COVID-19 among patients with hypertension in the Philippine CORONA Study.European journal of medical research · 2023Article
- Ischemic strokes in COVID-19: risk factors, obesity paradox, and distinction between trigger and causal association.Frontiers in neurology · 2023Article
- Familial Hypercholesterolemia Patients with COVID-19-Effective Cholesterol-Lowering Therapy is Urgent both during and after Infection.Reviews in cardiovascular medicine · 2022Review
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5 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundWhile most large studies on the possible association of COVID-19 and stroke were done in high-income countries, only a few studies consisting of small sample populations have been done in low- to middle-income countries like the Philippines.
objectivesTo determine the risk factors of stroke among hospitalized COVID19 patients in the Philippines; to determine the possible association between these risk factors and stroke among the same cohort; and to determine if there is an association between mortality and stroke in this same group. METHODOLOGY: We obtained relevant clinical and neurological, including stroke data from the Philippine CORONA study, an observational study involving 10,881 patients with COVID-19 admitted in 37 referral hospitals from all over the Philippines.
resultsThe incidence of stroke among patients with COVID-19 was 3.4% (n = 367). There were more deaths among patients with stroke and COVID-19 than those without stroke and COVID-19 (42.2% vs 14.7%, p < 0.01). In addition, more patients with stroke were admitted in the ICU (43.3% vs 15.0%, p < 0.01) regardless of cause. Smoking (OR: 1.5, 95% CI: 1.3 to 1.7, p < 0.0001), hypertension (OR:1.75, 95% CI:1.53 to 1.97, p < 0.0001), presence of heart failure (OR: 1.4, 95% CI: 1.07 to 1.86, p = 0.01), presence of any neurologic co-morbidities (OR: 1.4, 95% CI:1.11 to 1.46, p = 0.004), and history of stroke (OR:2.3, 95% CI:1.82 to 2.97, p < 0.0001) had direct significant correlation with stroke; while being a health care worker (OR: 0.5, 95% CI: 0.33 to 0.70, p < 0.0004) had an inverse significant association with stroke.
conclusionCOVID-19 stroke patients in the Philippines have a higher mortality and ICU admission rates than patients with COVID-19 alone or COVID-19 stroke patients from developed countries. Our cohort has similar cardiovascular and metabolic risk factors to western patients with stroke, highlighting that COVID-19 may only have a small contribution to stroke incidence.
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