Evidence map›Paper›PMID 36113163›Full record

ArticleOperative neurosurgery (Hagerstown, Md.)2022

Wide Arterial Sparing Encephalo-Duro-Synangiosis for Moyamoya: Surgical Technique and Outcomes.

Demi Dawkins, Beverly Aagaard-Kienitz, Kelly Capel, Laura Eisenmenger, Alexey Samsonov, Yiping Li, Carolina Sandoval-Garcia, Bermans Iskandar

Erratum issuedOpen access · greenAbstract read
In one paragraph

Article in Operative neurosurgery (Hagerstown, Md.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Demi DawkinsDepartment of Neurosurgery, University of Tennessee Health Sciences/Semmes-Murphey Clinic, Memphis, Tennessee, USA.ORCID 0000-0002-1813-204
Beverly Aagaard-KienitzDepartment of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Kelly CapelDepartment of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Laura EisenmengerDepartment of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Alexey SamsonovDepartment of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Yiping LiDepartment of Neurosurgery, Inland Neurosurgery, Spokane, Washington, USA.
Carolina Sandoval-GarciaDepartment of Neurosurgery, University of Minnesota, Minneapolis, Minnesota, USA.
Bermans IskandarDepartment of Neurosurgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.ORCID 0000-0002-3856-1597
University of Wisconsin–Madison · USInland Northwest Health Services · USUniversity of Minnesota · USUniversity of Tennessee at Knoxville · US

Funding

University of Wisconsin Institute for Clinical and Translational ResearchUL1TR002373 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI ELIZABETH S BURNSIDE, Allan R. Brasier · 2017 to 2026
$75.9M
Wisconsin Alzheimer's Disease Research CenterP30AG062715 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI RICHARD J CHAPPELL · 2019 to 2026
$34.5M
Institutional Career Development CoreKL2TR002374 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI Bo Liu, Marin Leigh Schweizer · 2017 to 2026
$9.7M
NCATS NIH HHS KL2 TR002374NCATS NIH HHS UL1 TR002373NIA NIH HHS P30 AG062715
6 · The paper itself

Abstract

backgroundMoyamoya is managed by surgical revascularization, but no standardized method has yet been universally adopted.

objectiveTo describe a new indirect bypass technique for pediatric moyamoya, wide arterial sparing encephalo-duro-synangiosis (WASEDS), which provides a much wider area of revascularization with minimal compromise to the middle meningeal arterial tree compared with traditional procedures. Initially used as a salvage technique after failed encephalo-duro-arterio-synangiosis, its success later motivated its use as a first-line procedure.

methodsClinical and radiographic records of patients who underwent WASEDS for moyamoya from 2009 to 2020 were reviewed. Brain perfusion relative cerebral blood volume on the side of the WASEDS procedure was calculated. Two-tailed paired t tests were performed to identify the statistically significant differences ( P ≤ .05).

resultsWASEDS was successfully performed on 8 patients for a total of 14 cerebral hemispheres. Age ranged from 2 to 25 years. There were no mortalities. The average clinical and radiographic follow-up was 49.79 months (range 2-126 months), demonstrating improvement in neurological condition and no postoperative stroke and significant diminution or cessation of transient ischemic attacks in all patients. Relative cerebral blood volume increased 9.24% after the WASEDS procedure ( P = .012). There were no neurological complications. There were 2 pseudomeningoceles related to the extensive dural openings.

conclusionWASEDS is a safe and effective indirect revascularization technique for both primary and salvage techniques. It provides an extensive area of cortical revascularization with no compromise of the middle meningeal vasculature and subjective reports of early improvement in cognition and behavior. The main disadvantage is elevated risk of pseudomeningocele secondary to the large craniotomy.

Indexed as

Cerebral RevascularizationMoyamoya DiseaseAdolescentAdultChildChild, PreschoolCraniotomyHumansMiddle Cerebral ArteryVascular Surgical ProceduresYoung Adult

Identifiers

PMID36113163
PMCPMC10593263
OpenAlexW4296165108

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.