Evidence map›Paper›PMID 36113118›Full record

ArticleEuropean journal of ophthalmology2023

Multimodal ocular imaging in Proteus syndrome.

Annabella Salerni, Luca Scartozzi, Fabrizio Piccinni, Luigi Mosca, Roberta Mattei, Chiara Leoni, Roberta Onesimo, Giuseppe Zampino, Stanislao Rizzo

Abstract readCase Reports
In one paragraph

Article in European journal of ophthalmology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Annabella SalerniOphthalmology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCSS, Rome, Italy.
Luca ScartozziOphthalmology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCSS, Rome, Italy.ORCID 0000-0003-3571-7717
Fabrizio PiccinniOphthalmology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCSS, Rome, Italy.ORCID 0000-0002-9625-8123
Luigi MoscaOphthalmology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCSS, Rome, Italy.ORCID 0000-0003-4641-0841
Roberta MatteiOphthalmology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCSS, Rome, Italy.
Chiara LeoniCenter for Rare Diseases and Birth Defects, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy.
Roberta OnesimoCenter for Rare Diseases and Birth Defects, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy.
Giuseppe ZampinoCenter for Rare Diseases and Birth Defects, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy.
Stanislao RizzoOphthalmology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCSS, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this report we illustrate the ophthalmologic assessment of two patients affected by Proteus Syndrome (PS), an extremely rare genetic disorder. Case #1 describes a 26 year old male patient followed for multiple ophthalmic anomalies: a limbal dermoid cyst, a unilateral cataract, bilateral nystagmus, severe myopia and unilateral optic nerve head drusen. Case #2 describes a 20 year old female patient referred to our Ophthalmology Department for a routine ophthalmologic evaluation after being treated for 3 years with Miransertib (an experimental AKT-pathway inhibitor). Both patients underwent a complete ophthalmologic examination and a multimodal imaging evaluation. The multimodal imaging approach has revealed useful to evaluate both cases in detail and to keep track of disease evolution over time, moreover providing helpful features to further characterize this rare syndrome.

Indexed as

Abnormalities, MultipleEye AbnormalitiesMyopiaNystagmus, PathologicProteus SyndromeAdultDiagnostic ImagingFemaleHumansMaleYoung Adultlimbal dermoid cystmiransertibmyopic chorioretinopathyoptic nerve drusenProteus syndrome

Identifiers

PMID36113118
PMCPMC10469497

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.