Evidence map›Paper›PMID 36112512›Full record

ArticleContact dermatitis2023

Exclusion of Disperse Orange 3 is possible from the textile dye mix present in the Swedish baseline patch test series. A study by the Swedish Contact Dermatitis Research Group.

Marléne Isaksson, Annarita Antelmi, Jakob Dahlin, Joanna Stenton, Cecilia Svedman, Erik Zimerson, Bo Glas, Lina Hagvall, Maria Lagrelius, Anna Löwnertz and 3 more

Abstract read
In one paragraph

Article in Contact dermatitis, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Marléne IsakssonDepartment of Occupational and Environmental Dermatology, Lund University, Skane University Hospital, Malmö, Sweden.ORCID https://orcid.org/0000-0002-9005-0962
Annarita AntelmiDepartment of Occupational and Environmental Dermatology, Lund University, Skane University Hospital, Malmö, Sweden.
Jakob DahlinDepartment of Occupational and Environmental Dermatology, Lund University, Skane University Hospital, Malmö, Sweden.
Joanna StentonDepartment of Occupational and Environmental Dermatology, Lund University, Skane University Hospital, Malmö, Sweden.
Cecilia SvedmanDepartment of Occupational and Environmental Dermatology, Lund University, Skane University Hospital, Malmö, Sweden.ORCID https://orcid.org/0000-0003-4797-0269
Erik ZimersonDepartment of Occupational and Environmental Dermatology, Lund University, Skane University Hospital, Malmö, Sweden.
Bo GlasDepartment of Public Health and Clinical Medicine, Dermatology and Venereology, Umeå University, Umeå, Sweden.
Lina HagvallDepartment of Dermatology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
Maria LagreliusOccupational and Environmental Dermatology, CAMM, Stockholm County Council and Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden.ORCID https://orcid.org/0000-0002-8506-4577
Anna LöwnertzDivision of Dermatology and Venereology, Ryhov County Hospital, Jönköping, Sweden.
Laura MalinauskieneFaculty of Medicine, Institute of Clinical Medicine, Clinic of Chest Diseases, Immunology and Allergology, Vilnius University, Vilnius, Lithuania.ORCID https://orcid.org/0000-0001-5834-5915
Mihaly MaturaDepartment of Dermatology, Skaraborgs Hospital, Skövde, Sweden.
Magnus BruzeDepartment of Occupational and Environmental Dermatology, Lund University, Skane University Hospital, Malmö, Sweden.ORCID https://orcid.org/0000-0002-2919-3227

Funding

Edvard Welander FoundationFinsen FoundationHudFonden
6 · The paper itself

Abstract

backgroundThe textile dye mix (TDM) 6.6% in petrolatum contains Disperse Blue (DB) 35, Disperse Yellow 3, Disperse Orange (DO) 1 and 3, Disperse Red 1 and 17, and DB 106 and 124. The most frequent allergen in TDM-positive patients is DO 3. Around 85% of para-phenylenediamine (PPD)-allergic dermatitis patients have been positive to DO 3. There has been a discussion to exclude DO 3 from TDM 6.6% because of strong simultaneous reactions to TDM and PPD.

objectivesTo study if DO 3 can be excluded from TDM 6.6%.

methodsPatch tests were performed on 1481 dermatitis patients with TDM 6.6%, TDM 7.0% (without DO 3 but the other disperse dyes at 1.0% each), DO 3 1.0%, and PPD 1.0% pet.

resultsContact allergy to TDM 6.6% was 3.6% and to TDM 7.0% was 3.0%. All 26 DO 3-positive patients were positive to PPD. The 44 patients positive to TDM 7.0% plus the 13 positive to PPD and TDM 6.6% but negative to TDM 7.0% were 57, outnumbering the 53 positive to TDM 6.6%.

conclusionTDM 7.0% can replace TDM 6.6% in the Swedish baseline series, since TDM 7.0% together with PPD 1.0% will detect patients with textile dye allergy.

Indexed as

Dermatitis, Allergic ContactAnthraquinonesAzo CompoundsColoring AgentsHumansPatch TestsSwedenTextilesAnthraquinonesAzo CompoundsColoring Agentsdisperse blue 35Disperse Orange 1Disperse Orange 3allergic contact dermatitiscontact allergydelayed hypersensitivitydisperse dyespatch testingtextile dermatitis

Identifiers

PMID36112512
PMCPMC10091765

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.