Evidence map›Paper›PMID 36112418›Full record

ArticleThe Journal of cell biology2022

Endosomal recycling defects link Huntington's disease with McLeod syndrome.

Elise Marsan, Eric J Huang

Open access · bronzeAbstract readComment
In one paragraph

Article in The Journal of cell biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Elise MarsanDepartment of Pathology, University of California, San Francisco, San Francisco, CA.ORCID 0000-0003-1975-290X
Eric J HuangDepartment of Pathology, University of California, San Francisco, San Francisco, CA.ORCID 0000-0002-5381-3801
University of California, San Francisco · US

Funding

Development and Expansion of the Human Cerebral CortexR35NS097305 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KRIEGSTEIN, ARNOLD · 2017 to 2024
$8.5M
Endolysosomal defects in secretory autophagy and microglial toxicity in FTDR01AG057462 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jayanta Debnath, Eric J Huang · 2017 to 2026
$6.9M
Single Cell Analyses of Neuroimmune Dysfunctions in the Thalamocortical Circuit in FTLDR01AA027074 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUANG, ERIC J, KRIEGSTEIN, ARNOLD · 2018 to 2022
$3.3M
Progranulin deficiency and microglia senescence in neurodegenerationR01AG068290 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUANG, ERIC J · 2020 to 2024
$2.0M
Mechanisms of ER Stress and Neurodegeneration in Parkinson's DiseaseI01BX001108 · VA · VETERANS AFFAIRS MED CTR SAN FRANCISCO · PI Eric J Huang · 2011 to 2026
–
BLRD VA I01 BX001108NIAAA NIH HHS R01 AA027074NIA NIH HHS R01 AG057462NIA NIH HHS R01 AG068290NIH HHS R01 AA027074NINDS NIH HHS R35 NS097305
6 · The paper itself

Abstract

Chhetri and colleagues (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202112073) show that Rab11-mediated endosomal recycling regulates cell surface expression of McLeod syndrome protein XK. Mutant huntingtin interferes with the recycling of XK to the cell surface and significantly reduces manganese transport across cell membrane.

Indexed as

Amino Acid Transport Systems, NeutralEndosomesHuntington DiseaseManganeseNeuroacanthocytosisCell MembraneHumansrab11 GTP-Binding Proteinsrab GTP-Binding ProteinsAmino Acid Transport Systems, NeutralManganeserab11 GTP-Binding Proteinsrab GTP-Binding ProteinsXK protein, human

Identifiers

PMID36112418
PMCPMC9485561
OpenAlexW4296028937

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.