Evidence map›Paper›PMID 36112398›Full record

ArticleJournal of surgical oncology2023

Survival and failure modes of the Compress® spindle and expandable distal femur endoprosthesis among pediatric patients: A multi-institutional study.

Kara S Tanaka, Veronica R Andaya, Steven W Thorpe, Kenneth R Gundle, James B Hayden, Yee-Cheen Duong, Raffi S Avedian, David G Mohler, Lee J Morse, Melissa N Zimel and 7 more

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of surgical oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 1 country.

Kara S TanakaDepartment of Orthopaedic Surgery, University of California, San Francisco, San Francisco, California, USA.ORCID http://orcid.org/0000-0003-0825-186X
Veronica R AndayaDepartment of Orthopaedic Surgery, University of California, San Francisco, San Francisco, California, USA.
Steven W ThorpeDepartment of Orthopaedic Surgery, University of California, Davis, Sacramento, California, USA.
Kenneth R GundleDepartment of Orthopaedic Surgery, Oregon Health and Science University, Portland, Oregon, USA.ORCID http://orcid.org/0000-0003-0451-0561
James B HaydenDepartment of Orthopaedic Surgery, Oregon Health and Science University, Portland, Oregon, USA.
Yee-Cheen DuongDepartment of Orthopaedic Surgery, Oregon Health and Science University, Portland, Oregon, USA.ORCID http://orcid.org/0000-0002-3476-5832
Raffi S AvedianDepartment of Orthopaedic Surgery, Stanford University Medical Center, Palo Alto, California, USA.
David G MohlerDepartment of Orthopaedic Surgery, Stanford University Medical Center, Palo Alto, California, USA.
Lee J MorseDepartment of Orthopaedic Surgery, Kaiser Oakland and South San Francisco, South San Francisco, California, USA.
Melissa N ZimelDepartment of Orthopaedic Surgery, University of California, San Francisco, San Francisco, California, USA.
Richard J O'DonnellDepartment of Orthopaedic Surgery, University of California, San Francisco, San Francisco, California, USA.
Andrew FangDepartment of Orthopaedic Surgery, Kaiser Oakland and South San Francisco, South San Francisco, California, USA.
Robert Lor RandallDepartment of Orthopaedic Surgery, University of California, Davis, Sacramento, California, USA.ORCID http://orcid.org/0000-0002-3660-774X
Tina H TranDepartment of Orthopaedic Surgery, Oregon Health and Science University, Portland, Oregon, USA.ORCID http://orcid.org/0000-0003-1376-2197
Christin NewDepartment of Orthopaedic Surgery, Stanford University Medical Center, Palo Alto, California, USA.
Rosanna L WustrackDepartment of Orthopaedic Surgery, University of California, San Francisco, San Francisco, California, USA.ORCID https://orcid.org/0000-0001-8512-5344
other members of Study Group FORCE
University of California, San Francisco · USOregon Health & Science University · USStanford Medicine · USKaiser Permanente Oakland Medical Center · USUniversity of California Davis Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundExpandable endoprostheses can be used to equalize limb length for pediatric patients requiring reconstruction following large bony oncologic resections. Outcomes of the Compress® Compliant Pre-Stress (CPS) spindle paired with an Orthopedic Salvage System expandable distal femur endoprosthesis have not been reported.

methodsWe conducted a multi-institutional retrospective study of pediatric patients with distal femoral bone sarcomas reconstructed with the above endoprostheses. Statistical analysis utilized Kaplan-Meier survival technique and competing risk analysis.

resultsThirty-six patients were included from five institutions. Spindle survivorship was 86.3% (95% confidence interval [CI], 67.7-93.5) at 10 years. Two patients had a failure of osseointegration (5.7%), both within 12 months. Twenty-two (59%) patients had 70 lengthening procedures, with mean expansions of 3.2 cm (range: 1-9) over 3.4 surgeries. The expandable mechanism failed in eight patients with a cumulative incidence of 16.1% (95% CI, 5.6-31.5) at 5 years. Twenty-nine patients sustained International Society of Limb Salvage failures requiring 63 unplanned surgeries. Periprosthetic joint infection occurred in six patients (16.7%). Limb preservation rate was 91% at 10 years.

conclusionsThere is a high rate of osseointegration of the Compress® spindle among pediatric patients when coupled with an expandable implant. However, there is a high rate of expansion mechanism failure and prosthetic joint infections requiring revision surgery. LEVEL OF EVIDENCE: Level IV, therapeutic study.

Indexed as

Bone NeoplasmsFemoral NeoplasmsChildFemurHumansOsteotomyProsthesis DesignProsthesis FailureProsthesis ImplantationReoperationRetrospective StudiesRisk FactorsTreatment Outcomeexpandable endoprosthesislimb-salvage surgerypediatric sarcoma

Identifiers

PMID36112398
PMCPMC10087226
OpenAlexW4296031313

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.