Evidence map›Paper›PMID 36112264›Full record

ArticleCell biology and toxicology2023

Extracellular vesicles derived from bone marrow mesenchymal stem cells loaded on magnetic nanoparticles delay the progression of diabetic osteoporosis via delivery of miR-150-5p.

Chen Xu, Zhaodong Wang, Yajun Liu, Bangguo Wei, Xiangyu Liu, Keyou Duan, Pinghui Zhou, Zhao Xie, Min Wu, Jianzhong Guan

Open access · hybridAbstract read
In one paragraph

Article in Cell biology and toxicology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Extracellular vesicle-mediated crosstalk in bone: miR-150-5p as a mechanosensitive regulator of osteoclastogenesis.Molecular therapy : the journal of the American Society of Gene Therapy · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Role of microRNA in Diabetic Osteoporosis.Molecular biotechnology · 2025
    Review
  8. Review
  9. Epigenetic factors associated with peri-implantitis: a review.Journal of Zhejiang University. Science. B · 2025
    Review
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  11. Review
  12. Review
  13. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Chen XuDepartment of Orthopedics, the First Affiliated Hospital of Bengbu Medical College, No. 287, Changhuai Road, Bengbu, 233000, Anhui Province, People's Republic of China.
Zhaodong WangDepartment of Orthopedics, the First Affiliated Hospital of Bengbu Medical College, No. 287, Changhuai Road, Bengbu, 233000, Anhui Province, People's Republic of China.
Yajun LiuDepartment of Orthopedics, the First Affiliated Hospital of Bengbu Medical College, No. 287, Changhuai Road, Bengbu, 233000, Anhui Province, People's Republic of China.
Bangguo WeiDepartment of Orthopedics, the First Affiliated Hospital of Bengbu Medical College, No. 287, Changhuai Road, Bengbu, 233000, Anhui Province, People's Republic of China.
Xiangyu LiuDepartment of Orthopedics, the First Affiliated Hospital of Bengbu Medical College, No. 287, Changhuai Road, Bengbu, 233000, Anhui Province, People's Republic of China.
Keyou DuanDepartment of Orthopedics, the First Affiliated Hospital of Bengbu Medical College, No. 287, Changhuai Road, Bengbu, 233000, Anhui Province, People's Republic of China.
Pinghui ZhouDepartment of Orthopedics, the First Affiliated Hospital of Bengbu Medical College, No. 287, Changhuai Road, Bengbu, 233000, Anhui Province, People's Republic of China.
Zhao XieThird Military Medical University of Chinese PLA, Chongqing, 400038, People's Republic of China.
Min WuDepartment of Orthopedics, the First Affiliated Hospital of Bengbu Medical College, No. 287, Changhuai Road, Bengbu, 233000, Anhui Province, People's Republic of China. minwu2021@126.com.ORCID 0000-0003-4229-5559
Jianzhong GuanDepartment of Orthopedics, the First Affiliated Hospital of Bengbu Medical College, No. 287, Changhuai Road, Bengbu, 233000, Anhui Province, People's Republic of China. jianzhongguan2021@126.com.ORCID 0000-0003-2388-0242
First Affiliated Hospital of Bengbu Medical College · CNJinan University · CNArmy Medical University · CNBengbu Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracellular vesicles derived from bone marrow mesenchymal stem cells (BMSC-EVs) are emerged as carriers of therapeutic targets against bone disorders, yet its isolation and purification are limited with recent techniques. Magnetic nanoparticles (MNPs) can load EVs with a unique targeted drug delivery system. We constructed gold-coated magnetic nanoparticles (GMNPs) by decorating the surface of the Fe

Indexed as

Diabetes MellitusExtracellular VesiclesMagnetite NanoparticlesMesenchymal Stem CellsMicroRNAsOsteoporosisAnimalsbeta CateninCell DifferentiationMatrix Metalloproteinase 14RatsRats, Sprague-DawleySilicon Dioxidebeta CateninMagnetite NanoparticlesMatrix Metalloproteinase 14MicroRNAsMIRN150 microRNA, ratSilicon DioxideBone marrow mesenchymal stem cellsDiabetic osteoporosisExtracellular vesiclesMagnetic nanoparticlesMicroRNA-150-5pMMP14OsteogenesisWnt/β-catenin pathway

Identifiers

PMID36112264
PMCPMC10425527
OpenAlexW4296033024

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.