Evidence map›Paper›PMID 36112234›Full record

ArticleClinical research in cardiology : official journal of the German Cardiac Society2023

Cardiac magnetic resonance abnormalities in patients with acute myocarditis proven by septal endomyocardial biopsy.

Giovanni Peretto, Marco Merlo, Piero Gentile, Aldostefano Porcari, Anna Palmisano, Davide Vignale, Paola Sormani, Stefania Rizzo, Monica De Gaspari, Cristina Basso and 6 more

Registry-linked trialAbstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04521790 (Role of Endomyocardial Biopsy and Aetiology-based Treatment in Patients With Inflammatory Heart Disease in Arrhythmic and Non-arrhythmic Clinical Presentations), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04521790 recruitingnot on this map

Role of Endomyocardial Biopsy and Aetiology-based Treatment in Patients With Inflammatory Heart Disease in Arrhythmic and Non-arrhythmic Clinical Presentations: an Integrated Approach for the Optimal Diagnostic and Therapeutic Management

Typeobservational_patient_registrySponsorScientific Institute San RaffaeleRan2018 to 2035Enrolled1,000ConditionsMyocarditis, Ventricular Arrythmia, Inflammatory Cardiomyopathy, Genetic PredispositionArmssupport treatment, cardiac medical treatment, aetiology-specific treatment, device implant, arrhythmia ablation
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Giovanni PerettoDepartment of Cardiac Electrophysiology and Arrhythmology, IRCCS San Raffaele Scientific Institute, Milan, Italy. peretto.giovanni@hsr.it.ORCID http://orcid.org/0000-0003-1815-4000
Marco MerloCenter for Diagnosis and Treatment of Cardiomyopathies, Cardiovascular Department, Azienda Sanitaria Universitaria Giuliano-Isontina (ASUGI), University of Trieste, Trieste, Italy.
Piero GentileDe Gasperis Cardio ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
Aldostefano PorcariCenter for Diagnosis and Treatment of Cardiomyopathies, Cardiovascular Department, Azienda Sanitaria Universitaria Giuliano-Isontina (ASUGI), University of Trieste, Trieste, Italy.
Anna PalmisanoExperimental Imaging Center, Radiology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Davide VignaleExperimental Imaging Center, Radiology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Paola SormaniDe Gasperis Cardio ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
Stefania RizzoDepartment of Cardiac Thoracic Vascular Sciences and Public Health, Cardiovascular Pathology, Padua University, Padua, Italy.
Monica De GaspariDepartment of Cardiac Thoracic Vascular Sciences and Public Health, Cardiovascular Pathology, Padua University, Padua, Italy.
Cristina BassoDepartment of Cardiac Thoracic Vascular Sciences and Public Health, Cardiovascular Pathology, Padua University, Padua, Italy.
Paolo Della BellaDepartment of Cardiac Electrophysiology and Arrhythmology, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Simone SalaDepartment of Cardiac Electrophysiology and Arrhythmology, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Enrico AmmiratiDe Gasperis Cardio ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
Gianfranco SinagraCenter for Diagnosis and Treatment of Cardiomyopathies, Cardiovascular Department, Azienda Sanitaria Universitaria Giuliano-Isontina (ASUGI), University of Trieste, Trieste, Italy.
Antonio EspositoSchool of Medicine, Vita-Salute San Raffaele University, Via Olgettina 58, Milan, Italy.
Patrizia PedrottiDe Gasperis Cardio ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrevious studies suggest low diagnostic sensitivity of cardiac magnetic resonance (CMR) imaging based on Lake Louise criteria (LLC) to identify patients with complicated presentations of acute myocarditis (AM). We evaluated classic and updated LLC in patients with AM proven by right ventricular septal endomyocardial biopsy (RVS-EMB).

methodsFrom an initial population of 499 patients with clinically suspected AM from a multicenter retrospective cohort, we included 74 patients with histologically proven myocarditis on RVS-EMB and available CMR within 30 days since admission. The prevalence of total and septal CMR abnormalities [namely, T2-weighted images (T2W), late gadolinium enhancement (LGE), T2 and T1 mapping, and extracellular volume (ECV)] were assessed in patients with complicated vs. uncomplicated AM.

resultsAmong 74 patients [mean age 38 ± 15 years, 65% males, left ventricular ejection fraction (LVEF) 40 ± 18%] with RVS-EMB-proven AM, 53 (72%) had a complicated presentation. The classic LLC were positive in 56/74 patients (76%), whereas the updated ones were positive in 41/41 of cases (100%). Septal involvement, documented in 48/74 patients (65%) by conventional T2W/LGE and in 39/41 cases (95%) by mapping techniques (p < 0.001), was more common in patients with complicated AM. In the 41 patients undergoing both evaluations, CMR sensitivity for myocarditis was 85% for the classic LLC vs. 100% for the updated LLC (p = 0.006).

conclusionIn patients with myocarditis on RVS-EMB, CMR using updated LLC has high sensitivity in the detection of AM when performed within 30 days. Septal abnormalities are more common in patients with complicated AM.

Indexed as

Heart Defects, CongenitalMyocarditisAdultBiopsyContrast MediaFemaleGadoliniumHumansMagnetic Resonance ImagingMagnetic Resonance Imaging, CineMagnetic Resonance SpectroscopyMaleMiddle AgedMyocardiumRetrospective StudiesStroke VolumeContrast MediaGadoliniumCardiac magnetic resonanceEndomyocardial biopsyMyocarditisParametric mappingRight ventricleSeptum

Identifiers

PMID36112234

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Registered trials

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