Evidence map›Paper›PMID 36112232›Full record

ArticleBrain structure & function2022

The critical role of the orbitofrontal cortex for regret in an economic decision-making task.

Tingting Zhang, Qiuzhu Zhang, Jiaqi Wu, Min Wang, Wenjuan Li, Jing Yan, Junjun Zhang, Zhenlan Jin, Ling Li

Abstract read
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In one paragraph

Article in Brain structure & function, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tingting ZhangMOE Key Lab for Neuroinformation, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, Center for Psychiatry and Psychology, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 610054, China.
Qiuzhu ZhangMOE Key Lab for Neuroinformation, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, Center for Psychiatry and Psychology, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 610054, China.
Jiaqi WuMOE Key Lab for Neuroinformation, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, Center for Psychiatry and Psychology, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 610054, China.
Min WangMOE Key Lab for Neuroinformation, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, Center for Psychiatry and Psychology, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 610054, China.
Wenjuan LiMOE Key Lab for Neuroinformation, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, Center for Psychiatry and Psychology, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 610054, China.
Jing YanMOE Key Lab for Neuroinformation, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, Center for Psychiatry and Psychology, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 610054, China.
Junjun ZhangMOE Key Lab for Neuroinformation, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, Center for Psychiatry and Psychology, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 610054, China.
Zhenlan JinMOE Key Lab for Neuroinformation, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, Center for Psychiatry and Psychology, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 610054, China. jinzl@uestc.edu.cn.
Ling LiMOE Key Lab for Neuroinformation, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, Center for Psychiatry and Psychology, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 610054, China. liling@uestc.edu.cn.

Funding

Fundamental Research Funds for the Central Universities ZYGX2020FRJH014Higher Education Discipline Innovation Project B12027National Natural Science Foundation of China 61773092National Natural Science Foundation of China 61773096National Natural Science Foundation of China 62176045Sichuan Province Science and Technology Innovation Cultivation Project 2022014
6 · The paper itself

Abstract

Regret affects decision-making behavior, which is mediated by a cognitive process known as counterfactual thinking in economic science. Several studies indicate that orbitofrontal cortex (OFC) plays a crucial role in decision-making behavior. However, the neural correlates of regret trait and the function of the OFC in decision-making remain unclear. In this study, we employed a typical monetary decision-making task, a modified 'Wheel of Fortune gamble' paradigm, to investigate decision-making behavior and its neural mechanism. We combined voxel-based morphometry (VBM) and task-evoked functional magnetic resonance imaging (fMRI) analyses to explore the neural substrates of regret trait. VBM analyses revealed that individual Regret Scale Score was negatively associated with the gray-matter volume (GMV) in the frontal and temporal areas, including the bilateral OFC. These results indicate that individuals with high regret trait have smaller GMV in these areas. Moreover, we found stronger task-evoked activation of the left OFC in high regret trait individuals during the decision-maker's choice (choose conditions) phase, whereas we did not find this relationship in computer-selected's (follow conditions) choice phase. Using generalized psychophysiological interactions (PPI) analysis, we further found that the functional connectivity of the left OFC to right inferior frontal gyrus and left cerebellum was stronger in the complete feedback choose condition (under regret theoretical framework) than partial feedback choose condition (under disappointment theoretical framework). These findings verify the critical role of the OFC in the decision-making, more importantly, provide novel insights into the morphological and functional substrates of individual regret trait.

Indexed as

EmotionsPrefrontal CortexDecision MakingFrontal LobeGray MatterHumansMagnetic Resonance ImagingDecision-makingDynamic regression modelOFCPPIRegretVBM

Identifiers

PMID36112232

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.