Evidence map›Paper›PMID 36112066›Full record

ArticleJournal of clinical research in pediatric endocrinology2024

Juvenile Granulosa Cell Tumor Mimicking HAIR-AN in a 4-year-old: A Case Report

Rachel Choe Kim, Iliya Goldberg, Trevor Van Brunt, Hamama Tul-Bushra, Rebecca Batiste, Andrew H Lane, Helen Hsieh

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical research in pediatric endocrinology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Rachel Choe KimStony Brook University, Renaissance Faculty of Medicine, New York, USAORCID 0000-0002-8750-0862
Iliya GoldbergStony Brook University, Renaissance Faculty of Medicine, Department of Surgery, New York, USAORCID 0000-0003-4310-2296
Trevor Van BruntStony Brook University, Renaissance Faculty of Medicine, New York, USAORCID 0000-0001-6979-7124
Hamama Tul-BushraStony Brook University, Renaissance Faculty of Medicine, Department of Pathology, New York, USAORCID 0000-0001-5833-2137
Rebecca BatisteStony Brook University, Renaissance Faculty of Medicine, Department of Pathology, New York, USAORCID 0000-0001-9667-7734
Andrew H LaneStony Brook Children’s Hospital, Clinic of Pediatrics, New York, USAORCID 0000-0002-9837-0282
Helen HsiehStony Brook University, Renaissance Faculty of Medicine, Department of Surgery, Division of Pediatric Surgery, New York, USAORCID 0000-0001-5226-1921
Stony Brook School · USStony Brook Children's Hospital · USStony Brook University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Predominantly androgen secreting juvenile granulosa cell tumors (JGCT) are uncommon and few reports have been published. We present a case of a JGCT that presented with signs of prepubertal hyperandrogenism and insulin resistance to highlight the possible interaction between hyperandrogenemia and hyperinsulinism. A 4-year-old girl presented with acanthosis nigricans and hyperinsulinism, mimicking the hyperandrogenism, insulin resistance and acanthosis nigricans syndrome at an age much younger than is typical for this diagnosis. Laboratory studies revealed elevated insulin, inhibin A and B, and total testosterone. All laboratory results normalized after unilateral salpingo-oophorectomy. The final diagnosis was Stage 1A JGCT. This case highlights the importance of including ovarian tumors in the differential diagnosis when considering causes of virilization and insulin resistance. This case also suggests a potential relationship between excess testosterone secretion and hyperinsulinemia and strengthens evidence that hyperandrogenemia may promote hyperinsulinism in ovarian disease.

Indexed as

Granulosa Cell TumorHyperandrogenismOvarian NeoplasmsAcanthosis NigricansChild, PreschoolDiagnosis, DifferentialFemaleHumansHyperinsulinismInsulin Resistancehyperandrogenisminsulin resistanceJuvenile granulosa cell tumor

Identifiers

PMID36112066
PMCPMC11590726
OpenAlexW4296032792

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.