ArticleActa anaesthesiologica Scandinavica2023
Impact of hyperoxia and phenylephrine on cerebral oxygenation: An experimental clinical study.
Article in Acta anaesthesiologica Scandinavica, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 6 citations in OpenAlex.
- Effect of Ephedrine versus Phenylephrine on Postoperative Delirium in Elderly Patients Undergoing Total Hip or Knee Arthroplasty: A Randomized Controlled Trial.Drug design, development and therapy · 2025Trial
- Differential effects of phenylephrine on brain versus skeletal muscle microvascular perfusion: an in vivo laboratory study using translational rodent models.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2026Article
- In vivo optical assessment of cerebral and skeletal muscle microvascular response to phenylephrine.FASEB bioAdvances · 2024Article
- The Impact of Inotropes and Vasopressors on Cerebral Oxygenation in Patients with Traumatic Brain Injury and Subarachnoid Hemorrhage: A Narrative Review.Brain sciences · 2024Review
- Impact of hyperoxia and phenylephrine on cerebral oxygenation: An experimental clinical study.Acta anaesthesiologica Scandinavica · 2023Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundOxygen supply to the brain is of special importance during intracranial surgery because it may be compromised by intracranial pathology. A high arterial blood pressure (mean arterial pressure above 80 mmHg) and a high arterial oxygen tension (PaO
methodsIn this experimental study, we included 17 adult patients scheduled for elective craniotomy. After securing a stable baseline of the oxygen probe, PbtO
resultsWe obtained complete data sets in 11 patients undergoing the FiO
conclusionIn patients undergoing craniotomy under general anaesthesia, brain tissue oxygen tension increased with a high inspiratory oxygen fraction but remained unchanged after a bolus dose of phenylephrine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.