ArticleHuman brain mapping2023
The role of ascending arousal network in patients with chronic insomnia disorder.
Article in Human brain mapping, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- The altered hypothalamic network functional connectivity in chronic insomnia disorder and regulation effect of acupuncture: a randomized controlled neuroimaging study.BMC complementary medicine and therapies · 2024Trial
- Altered Individualized Structural Covariance Networks Underlie Depressive and Anxiety Symptoms in Chronic Insomnia Disorder: A Dynamic Time Warping Graph Theory Study.Brain and behavior · 2026Article
- Effects of transcutaneous auricular vagus nerve stimulation on patients with post-stroke insomnia: a randomized controlled trial protocol.Frontiers in psychiatry · 2026Article
- Abnormal functional activity in the cerebellar crus can distinguish patients with migraine with comorbid insomnia.Frontiers in neuroscience · 2026Article
- Multivariate Pattern Analysis of fMRI Reveals Striato-Cortical Network Changes in Myoclonus-Dystonia.European journal of neurology · 2025Article
- Pathophysiological Insights and Multimodal Interventions in Chronic Tinnitus, Anxiety, and Sleep Disorders.Nature and science of sleep · 2025Review
- Article
- Efficacy and safety of auricular acupressure on reduction of estazolam in patients with insomnia: a study protocol for a three-arm, blinded randomized controlled trial.BMC complementary medicine and therapies · 2024Article
- The brain in chronic insomnia and anxiety disorder: a combined structural and functional fMRI study.Frontiers in psychiatry · 2024Article
- The role of ascending arousal network in patients with chronic insomnia disorder.Human brain mapping · 2023Article
- Abnormal functional connectivity in the habenula is associated with subjective hyperarousal state in chronic insomnia disorder.Frontiers in neurology · 2023Article
- Dynamic changes in fractional amplitude of low-frequency fluctuations in patients with chronic insomnia.Frontiers in neuroscience · 2022Article
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ascending arousal system plays a crucial role in individuals' consciousness. Recently, advanced functional magnetic resonance imaging (fMRI) has made it possible to investigate the ascending arousal network (AAN) in vivo. However, the role of AAN in the neuropathology of human insomnia remains unclear. Our study aimed to explore alterations in AAN and its connections with cortical networks in chronic insomnia disorder (CID). Resting-state fMRI data were acquired from 60 patients with CID and 60 good sleeper controls (GSCs). Changes in the brain's functional connectivity (FC) between the AAN and eight cortical networks were detected in patients with CID and GSCs. Multivariate pattern analysis (MVPA) was employed to differentiate CID patients from GSCs and predict clinical symptoms in patients with CID. Finally, these MVPA findings were further verified using an external data set (32 patients with CID and 33 GSCs). Compared to GSCs, patients with CID exhibited increased FC within the AAN, as well as increased FC between the AAN and default mode, cerebellar, sensorimotor, and dorsal attention networks. These AAN-related FC patterns and the MVPA classification model could be used to differentiate CID patients from GSCs with 88% accuracy in the first cohort and 77% accuracy in the validation cohort. Moreover, the MVPA prediction models could separately predict insomnia (data set 1, R
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