Evidence map›Paper›PMID 36111849›Full record

ArticleCurrent protocols2022

Purification of Self-Assembled DNA Tetrahedra Using Gel Electrophoresis.

Akul Patel, Vibhav Valsangkar, Ken Halvorsen, Arun Richard Chandrasekaran

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current protocols, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. The role of size in biostability of DNA tetrahedra.Chemical communications (Cambridge, England) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Akul PatelThe RNA Institute, University at Albany, State University of New York, New York.
Vibhav ValsangkarThe RNA Institute, University at Albany, State University of New York, New York.
Ken HalvorsenThe RNA Institute, University at Albany, State University of New York, New York.
Arun Richard ChandrasekaranThe RNA Institute, University at Albany, State University of New York, New York.

Funding

Manipulating nucleic acids: applications in RNA biosensing, single-molecule analysis, and DNA nanotechnologyR35GM124720 · NIGMS · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI Ken A Halvorsen · 2017 to 2026
$4.6M
DNA Nanostructures as siRNA Delivery Vehicles for Alzheimer's TherapyR03AG076599 · NIA · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI CHANDRASEKARAN, ARUN RICHARD · 2022 to 2023
$425k
NIA NIH HHS R03 AG076599NIA NIH HHS R03AG076599NIGMS NIH HHS R35 GM124720NIGMS NIH HHS R35GM124720NIH
6 · The paper itself

Abstract

DNA nanostructures have found applications in a variety of fields such as biosensing, drug delivery, cellular imaging, and computation. Several of these applications require purification of the DNA nanostructures once they are assembled. Gel electrophoresis-based purification of DNA nanostructures is one of the methods used for this purpose. Here, we describe a step-by-step protocol for a gel-based method to purify self-assembled DNA tetrahedra. With further optimization, this method could also be adapted for other DNA nanostructures. © 2022 Wiley Periodicals LLC. Basic Protocol: Purification of self-assembled DNA tetrahedra.

Indexed as

DNANanostructuresDrug Delivery SystemsElectrophoresisDNADNA nanotechnologyDNA tetrahedragel electrophoresispurificationself-assembly

Identifiers

PMID36111849
PMCPMC9494925

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.