Evidence map›Paper›PMID 36111787›Full record

ArticleeLife2022

Sociosexual behavior requires both activating and repressive roles of

Jennifer M Lin, Tyler A Mitchell, Megan Rothstein, Alison Pehl, Ed Zandro M Taroc, Raghu R Katreddi, Katherine E Parra, Damian G Zuloaga, Marcos Simoes-Costa, Paolo Emanuele Forni

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Jennifer M Lin *Department of Biological Sciences, University at Albany, State University of New York, Albany, United States.ORCID 0000-0002-9197-0816
Tyler A Mitchell *Department of Biological Sciences, University at Albany, State University of New York, Albany, United States.ORCID 0000-0002-9647-6024
Megan RothsteinDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, United States.
Alison PehlDepartment of Biological Sciences, University at Albany, State University of New York, Albany, United States.
Ed Zandro M TarocDepartment of Biological Sciences, University at Albany, State University of New York, Albany, United States.
Raghu R KatreddiDepartment of Biological Sciences, University at Albany, State University of New York, Albany, United States.
Katherine E ParraDepartment of Psychology, University at Albany, State University of New York, Albany, United States.
Damian G ZuloagaDepartment of Psychology, University at Albany, State University of New York, Albany, United States.
Marcos Simoes-CostaDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, United States.ORCID 0000-0003-1452-7068
Paolo Emanuele ForniDepartment of Biological Sciences, University at Albany, State University of New York, Albany, United States.ORCID 0000-0001-6547-3464
Albany State University · USCornell University · US

Funding

Understanding the role of the transcription factor Gli3 in Kallmann syndrome and normosmic forms of idiopathic hypogonadotropic hypogonadism.R01HD097331 · NICHD · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI Paolo E Forni · 2019 to 2026
$2.2M
Genomic control of neural crest identity by signaling systemsR01DE028576 · NIDCR · CORNELL UNIVERSITY · PI SIMOES-COSTA, MARCOS · 2019 to 2023
$1.9M
Molecular Mechanisms Controlling Differentiation and Circuit Formation of Vomeronasal Sensory NeuronsR01DC017149 · NIDCD · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI FORNI, PAOLO E · 2019 to 2023
$1.8M
Sex differences in corticotropin releasing factor receptor 1 regulation of stress-associated behaviorsR15MH118692 · NIMH · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI ZULOAGA, DAMIAN GABRIEL · 2019 to 2019
$462k
NICHD NIH HHS R01 HD097331NIDCD NIH HHS R01 DC017149NIDCR NIH HHS R01 DE028576NIMH NIH HHS R15 MH118692
6 · The paper itself

Abstract

Neuronal identity dictates the position in an epithelium, and the ability to detect, process, and transmit specific signals to specified targets. Transcription factors (TFs) determine cellular identity via direct modulation of genetic transcription and recruiting chromatin modifiers. However, our understanding of the mechanisms that define neuronal identity and their magnitude remain a critical barrier to elucidate the etiology of congenital and neurodegenerative disorders. The rodent vomeronasal organ provides a unique system to examine in detail the molecular mechanisms underlying the differentiation and maturation of chemosensory neurons. Here, we demonstrated that the identity of postmitotic/maturing vomeronasal sensory neurons (VSNs), and vomeronasal-dependent behaviors can be reprogrammed through the rescue of

Indexed as

Vomeronasal OrganAnimalsChromatinMiceMice, KnockoutSensory Receptor CellsTranscription FactorsChromatinTranscription Factorscellular plasticitydevelopmental biologymouseneurosciencenuronal identitysingle-cell RNA sequencingTfap2etranscription factorsvomeronasal

Identifiers

PMID36111787
PMCPMC9525060
OpenAlexW4296038450

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.