Evidence map›Paper›PMID 36111739›Full record

ArticleThe Journal of nutrition2023

Stability of Human-Milk Oligosaccharide Concentrations Over 1 Week of Lactation and Over 6 Hours Following a Standard Meal.

Paige K Berger, Hailey E Hampson, Kelsey A Schmidt, Tanya L Alderete, Annalee Furst, Chloe Yonemitsu, Ellen Demerath, Michael I Goran, David A Fields, Lars Bode

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 32 citations in OpenAlex.

  1. Trial
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  4. Observational
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  11. Environmental and Maternal Imprints on Infant Gut Metabolic Programming.bioRxiv : the preprint server for biology · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. The Association Between Maternal Psychological Health and Human Milk Oligosaccharide Composition.Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine · 2024
    Article
  17. Point-of-care human milk concentration by passive osmosis: comprehensive analysis of fresh human milk samples.Journal of perinatology : official journal of the California Perinatal Association · 2024
    Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Paige K BergerDepartment of Pediatric Newborn Medicine, Mass General Brigham, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-1670-5147
Hailey E HampsonDepartment of Pediatrics, The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Kelsey A SchmidtDepartment of Pediatrics, The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Tanya L AldereteDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA.
Annalee FurstDepartment of Pediatrics and Mother-Milk-Infant Center of Research Excellence (MOMI CORE), University of California, San Diego, La Jolla, CA, USA.
Chloe YonemitsuDepartment of Pediatrics and Mother-Milk-Infant Center of Research Excellence (MOMI CORE), University of California, San Diego, La Jolla, CA, USA.
Ellen DemerathDivision of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA.
Michael I GoranDepartment of Pediatrics, The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA.
David A FieldsDepartment of Pediatrics, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Lars BodeDepartment of Pediatrics and Mother-Milk-Infant Center of Research Excellence (MOMI CORE), University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0002-9914-9571
Children's Hospital of Los Angeles · USUniversity of California San Diego · USHarvard University · USUniversity of Colorado Boulder · USUniversity of Minnesota · USUniversity of Oklahoma Health Sciences Center · US

Funding

Maternal Obesity, Milk Composition, and Infant GrowthR01HD080444 · NICHD · UNIVERSITY OF MINNESOTA · PI ELLEN W. DEMERATH, DAVID A FIELDS · 2014 to 2026
$6.4M
Impact of Sugars and Human Milk Oligosaccharides on Infant Microbiome and ObesityR01DK110793 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GORAN, MICHAEL ISAAC, PETERSON, BRADLEY S · 2017 to 2024
$6.0M
Role of Human Milk Oligosaccharides on Brain Development in Preterm InfantsR00HD098288 · NICHD · BRIGHAM AND WOMEN'S HOSPITAL · PI BERGER, PAIGE KIMBERLY · 2022 to 2024
$686k
NICHD NIH HHS R00 HD098288NICHD NIH HHS R01 HD080444NIDDK NIH HHS R01 DK110793
6 · The paper itself

Abstract

backgroundOur previous studies revealed that human-milk oligosaccharides (HMOs) have health benefits for nursing infants and their concentrations change dynamically over 24 mo of lactation. Yet, the extent to which HMOs vary over the short term (days) and in response to acute factors such as maternal diet is unclear.

objectiveThe purpose of this study was to determine the stability of HMO concentrations over 7 d and in response to a standard meal and sugar-sweetened beverage (SSB) over 6 h.

methodsIn this ancillary study, lactating mothers were enrolled at 6 wk postpartum. Participants received in-person instructions and materials to complete procedures at home. In the 1-wk experiment (n = 11), mothers pumped a milk sample at 07:00 h for 7 consecutive days. In the 6-h experiment (n = 35), mothers pumped a milk sample after an overnight fast at 06:00 h and then consumed a standard meal plus SSB provided by the study team. Mothers pumped a milk sample every hour for 6 consecutive hours. Samples were analyzed for the 19 most abundant HMOs. Repeated-measures ANOVA was used to test changes in HMO concentrations over time, reported as F(dftime, dferror) = F value, P value.

resultsConcentrations of all assayed HMOs were stable over 7 consecutive days, including, for example, the most widely studied HMOs in relation to infant health: 2'-fucosyllactose (2'FL) [F(2,17) = 0.39, P = 0.65], disialyl-lacto-N-tetraose (DSLNT) [F(4, 37) = 0.60, P = 0.66], and lacto-N-neotetraose (LNnT) [F(3, 32) = 1.5, P = 0.23]. Concentrations of all assayed HMOs were stable in response to a standard meal plus SSB. For example, fasted baseline concentrations of 2'FL, DSLNT, and LNnT were 2310 ± 1620 μg/mL, 560 ± 290 μg/mL, and 630 ± 290 μg/mL, respectively, and there were no changes in 2'FL [F(4, 119) = 1.9, P = 0.13], DSLNT [F(4, 136) = 0.39, P = 0.83], and LNnT [F(4, 120) = 0.64, P = 0.63] over 6 consecutive hours.

conclusionsHMO concentrations are stable over 1 wk of lactation and are not acutely affected by a standard meal plus SSB in mothers.

Indexed as

Breast FeedingLactationFemaleHumansInfantMilk, HumanMothersOligosaccharidesOligosaccharidesbreastfeedingdiethuman-milk oligosaccharideslactationmother

Identifiers

PMID36111739
PMCPMC9839992
OpenAlexW4296038586

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.