Evidence map›Paper›PMID 36111313›Full record

ArticleInternational journal of nanomedicine2022

In-vivo (

Saiqa Bashir, Muhammad Siddique Awan, Muhammad Akhyar Farrukh, Ravi Naidu, Shahzad Akbar Khan, Nagina Rafique, Shaista Ali, Imran Hayat, Imtiaz Hussain, Muhammad Zubair Khan

Abstract read
In one paragraph

Article in International journal of nanomedicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Saiqa BashirDepartment of Food Science and Technology, University of Poonch, Rawalakot, Pakistan.
Muhammad Siddique AwanDepartment of Food Science and Technology, University of Poonch, Rawalakot, Pakistan.
Muhammad Akhyar FarrukhDepartment of Chemistry, Forman Christian College (A Chartered University), Lahore, Pakistan.ORCID 0000-0002-1118-8657
Ravi NaiduGlobal Centre for Environmental Remediation (GCER), University of Newcastle, Newcastle, Australia.
Shahzad Akbar KhanDepartment of Pathobiology, Faculty of Veterinary & Animal Sciences, University of Poonch, Rawalakot, Pakistan.
Nagina RafiqueDepartment of Food Science and Technology, University of Poonch, Rawalakot, Pakistan.ORCID 0000-0001-5979-3904
Shaista AliDepartment of Chemistry, Government College University of Lahore, Lahore, Pakistan.
Imran HayatDepartment of Food Science and Technology, University of Poonch, Rawalakot, Pakistan.
Imtiaz HussainDepartment of Food Science and Technology, University of Poonch, Rawalakot, Pakistan.
Muhammad Zubair KhanDepartment of Plant Breeding and Molecular Genetics, University of Poonch, Rawalakot, Pakistan.ORCID 0000-0002-4496-6099

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Recent advances in nanotechnology have given rise to the potential utilization of nanoparticles as food, nano-medicine/biomedicines. Patient: The study aimed to investigate the effects of nano-zinc oxide (nano-zinc) on the bio-assimilation of mineral (Zn) in mice, aged 3-6 weeks. Methods: ZnO nanoparticles were added to the basal diet as a supplement at amounts of 0.07, 0.14 and 0.21 mg/kg. The synthesized material was characterized by Fourier transform infrared spectrophotometer, particle size, scanning electron microscope, Thermogravimetric Analysis Thermal, X-ray diffraction spectrophotometer and Zeta potential. Results: In-vitro bioavailability of synthesized group ZnO (120 nm) was 43%, whereas for standard group ZnO (50 nm) was reported as 55%. In-vivo bioavailability of zinc oxide illustrated the maximum absorption level compared with the control. In-vivo toxicity was characterized as damage done to the liver and spleen tissues with a high dose of 0.21 mg/kg, while smaller doses indicated no toxic effects. Conclusion: The study provided important insights on the toxicological effects of ZnO nanoparticles, depending on dose rate and bio-assimilation, as well as particles, under various conditions (in-vitro and in-vivo). These findings will motivate further detailed research on nano-based medicine for alleviating malnutrition conditions.

Indexed as

NanoparticlesZinc OxideAnimalsMiceNanotechnologyParticle SizeZincZincZinc Oxidebioavailabilityfoodnanomedicinenanoparticlestoxicity

Identifiers

PMID36111313
PMCPMC9469211

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.