Evidence map›Paper›PMID 36111257›Full record

ArticleiScience2022

The Genetic contribution to solving the cocktail-party problem.

Samuel R Mathias, Emma E M Knowles, Josephine Mollon, Amanda L Rodrigue, Mary K Woolsey, Alyssa M Hernandez, Amy S Garrett, Peter T Fox, Rene L Olvera, Juan M Peralta and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Samuel R MathiasDepartment of Psychiatry, Boston Children's Hospital, Boston, MA 02115, USA.
Emma E M KnowlesDepartment of Psychiatry, Boston Children's Hospital, Boston, MA 02115, USA.
Josephine MollonDepartment of Psychiatry, Boston Children's Hospital, Boston, MA 02115, USA.
Amanda L RodrigueDepartment of Psychiatry, Boston Children's Hospital, Boston, MA 02115, USA.
Mary K WoolseyResearch Imaging Institute, University of Texas Health Science Center, San Antonio, TX 78229, USA.
Alyssa M HernandezResearch Imaging Institute, University of Texas Health Science Center, San Antonio, TX 78229, USA.
Amy S GarrettResearch Imaging Institute, University of Texas Health Science Center, San Antonio, TX 78229, USA.
Peter T FoxResearch Imaging Institute, University of Texas Health Science Center, San Antonio, TX 78229, USA.
Rene L OlveraSouth Texas Diabetes and Obesity Institute and Department of Human Genetics, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX 78520, USA.
Juan M PeraltaSouth Texas Diabetes and Obesity Institute and Department of Human Genetics, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX 78520, USA.
Satish KumarSouth Texas Diabetes and Obesity Institute and Department of Human Genetics, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX 78520, USA.
Harald H H GöringSouth Texas Diabetes and Obesity Institute and Department of Human Genetics, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX 78520, USA.
Ravi DuggiralaSouth Texas Diabetes and Obesity Institute and Department of Human Genetics, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX 78520, USA.
Joanne E CurranSouth Texas Diabetes and Obesity Institute and Department of Human Genetics, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX 78520, USA.
John BlangeroSouth Texas Diabetes and Obesity Institute and Department of Human Genetics, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX 78520, USA.
David C GlahnDepartment of Psychiatry, Boston Children's Hospital, Boston, MA 02115, USA.

Funding

Genetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI SCOTT Loren POMEROY, MUSTAFA SAHIN · 2021 to 2026
$9.4M
SOLAR-Eclipse Computational Tools for Imaging GeneticsR01EB015611 · NIBIB · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KOCHUNOV, PETER V. · 2012 to 2024
$5.0M
Imaging Genomics of the Aging BrainR01AG058464 · NIA · YALE UNIVERSITY · PI BLANGERO, JOHN, GLAHN, DAVID C · 2018 to 2022
$3.9M
NIA NIH HHS R01 AG058464NIBIB NIH HHS R01 EB015611NICHD NIH HHS P50 HD105351
6 · The paper itself

Abstract

Communicating in everyday situations requires solving the cocktail-party problem, or segregating the acoustic mixture into its constituent sounds and attending to those of most interest. Humans show dramatic variation in this ability, leading some to experience real-world problems irrespective of whether they meet criteria for clinical hearing loss. Here, we estimated the genetic contribution to cocktail-party listening by measuring speech-reception thresholds (SRTs) in 425 people from large families and ranging in age from 18 to 91 years. Roughly half the variance of SRTs was explained by genes (

Indexed as

GeneticsHealth sciencesHuman Genetics

Identifiers

PMID36111257
PMCPMC9468408

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.