Evidence map›Paper›PMID 36111254›Full record

ArticleiScience2022

A nano erythropoiesis stimulating agent for the treatment of anemia and associated disorders.

Monojit Das, Susmita Mondal, Ria Ghosh, Pritam Biswas, Ziad Moussa, Soumendra Darbar, Saleh A Ahmed, Anjan Kumar Das, Siddhartha Sankar Bhattacharya, Debasish Pal and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Nutritional Potential and Protective Effects ofFood science & nutrition · 2025
    Article
  2. Pharmaceuticals (Basel, Switzerland) · 2023
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 10 institutions in 5 countries.

Monojit DasDepartment of Zoology, Vidyasagar University, Rangamati, Midnapore 721102, India.
Susmita MondalDepartment of Chemical, Biological and Macromolecular Sciences, S. N. Bose National Centre for Basic Sciences, Block JD, Sector 3, Salt Lake, Kolkata 700106, India.
Ria GhoshDepartment of Chemical, Biological and Macromolecular Sciences, S. N. Bose National Centre for Basic Sciences, Block JD, Sector 3, Salt Lake, Kolkata 700106, India.
Pritam BiswasDepartment of Microbiology, St. Xavier's College, 30, Mother Teresa Sarani, Kolkata 700016, India.
Ziad MoussaDepartment of Chemistry, College of Science, United Arab Emirates University, P.O. Box 15551, Al Ain, United Arab Emirates.
Soumendra DarbarResearch and Development Division, Dey's Medical Stores (Mfg.) Ltd, 62, Bondel Road, Ballygunge, Kolkata 700019, India.
Saleh A AhmedDepartment of Chemistry, Faculty of Applied Science, Umm Al-Qura University, 21955 Makkah, Saudi Arabia.
Anjan Kumar DasDepartment of Pathology, Coochbehar Government Medical College and Hospital, Kotwali, Coochbehar 736101, India.
Siddhartha Sankar BhattacharyaDepartment of Zoology, Uluberia College, University of Calcutta, Uluberia, Howrah 711315, India.
Debasish PalDepartment of Zoology, Uluberia College, University of Calcutta, Uluberia, Howrah 711315, India.
Asim Kumar MallickDepartment of Pediatric Medicine, Nil Ratan Sircar Medical College and Hospital, Kolkata 700014, India.
Prantar ChakrabartiDepartment of Hematology, Vivekananda Institute of Medical Sciences, Kolkata 700026, India.
Jayanta Kumar KunduDepartment of Zoology, Vidyasagar University, Rangamati, Midnapore 721102, India.
Aniruddha AdhikariDepartment of Chemical and Biomolecular Engineering, UCLA Samueli School of Engineering, University of California, at Los Angeles (UCLA), Los Angeles, USA.
Samir Kumar PalDepartment of Zoology, Uluberia College, University of Calcutta, Uluberia, Howrah 711315, India.
University of Calcutta · INGovernment Medical College and Hospital · INNil Ratan Sircar Medical College and Hospital · INS.N. Bose National Centre for Basic Sciences · INSt. Xavier's College (Autonomous)Umm al-Qura University · SAUnited Arab Emirates University · AEUniversity of California, Los Angeles · USVidyasagar University · INVivekananda Institute of Medical Sciences · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The usual treatment for anemia and especially for anemia of inflammation (also called anemia of chronic disease) is supportive care with the target of improving the lifestyle of the patients. There is no effective medication to date for proper management. As the inflammation, erythropoiesis, and oxidative stress are the major concerns in this case, it inspired us to use a nano-erythropoietin stimulating agent (nano-ESA) made up of a nano-complex of manganese and citrate (Mn-citrate nano-complex), which has been hypothesized to have excellent antioxidant and anti-inflammatory mechanisms. Single oral dose of the nano-ESA efficiently prevented the onset of anemia as well as led to recovery from anemia in our phenylhydrazine (PHz)-intoxicated C57BL/6J mice model of anemia without any toxicological side effects. These preliminary findings may pave the way for an affordable and safe clinical use of the nano-ESA as a rapid recovery medication of anemia, especially anemia of inflammation.

Indexed as

Medical biochemistryMolecular medicineNanotechnology

Identifiers

PMID36111254
PMCPMC9468392
OpenAlexW4293565810

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.