ArticleFrontiers in surgery2022
Prognostic significance of the systemic immune inflammation index in patients with metastatic and unresectable pancreatic cancer.
Article in Frontiers in surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed.
- The Global Immune-Nutrition-Inflammation Index Is Associated with Survival Outcomes and Enhances Prognostic Discrimination in Metastatic Pancreatic Cancer.Medicina (Kaunas, Lithuania) · 2026Article
- Connecting systemic inflammation to prognosis in neuroendocrine neoplasms: a biomarker-based approach.Frontiers in medicine · 2026Article
- Mechanistic insights into hepatic metastasis of pancreatic cancer: molecular perspectives.Translational gastroenterology and hepatology · 2026Review
- Development and Validation of a Predictive Model for Occult Liver Metastasis in Pancreatic Ductal Adenocarcinoma Using Subjective Imaging and Clinical Data.Cancer medicine · 2025Article
- Development and validation of machine learning nomograms for predicting survival in stage IV pancreatic cancer: A retrospective study.World journal of gastrointestinal oncology · 2025Article
- The value of preoperative RDW for post-pancreatectomy haemorrhage and surgical prognosis in patients with pancreatic cancer: a retrospective study.BMC cancer · 2025Article
- Detecting the preoperative peripheral blood systemic immune-inflammation index (SII) as a tool for early diagnosis and prognosis of gallbladder cancer.BMC immunology · 2025Article
- Prognostic impact of inflammatory and nutritional biomarkers in pancreatic cancer.World journal of clinical oncology · 2025Article
- Association between the systemic immune-inflammation index and sarcopenia in older adults: a cross-sectional study.BMC geriatrics · 2025Article
- Geriatric Nutritional Risk Index (GNRI) and Prognostic Nutritional Index (PNI) Before Treatment as the Predictive Indicators for Bone Metastasis in Prostate Cancer Patients.International journal of general medicine · 2025Article
- The Association of Pretreatment Systemic Immune Inflammatory Response Index (SII) and Neutrophil-to-Lymphocyte Ratio (NLR) with Lymph Node Metastasis in Patients with Papillary Thyroid Carcinoma.International journal of general medicine · 2024Article
- Machine learning was used to predict risk factors for distant metastasis of pancreatic cancer and prognosis analysis.Journal of cancer research and clinical oncology · 2023Article
- Article
- Association between systemic immune-inflammation index and low muscle mass in US adults: a cross-sectional study.BMC public health · 2023Article
- Investigation of the prognostic role of systemic immunoinflammatory index in patients with acute pancreatitis.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2023Article
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8 authors.
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Abstract
Purpose: Systemic inflammatory markers may be predictors of the survival rate of patients with pancreatic cancer (PC). The aim of this work was to investigate the prognostic value of markers, mainly the systemic immune inflammation index (SII), in patients with metastatic and unresectable PC and to explore the relationship between markers and liver metastasis. Methods: Records of patients with metastatic and unresectable PC at the Affiliated Hospital of Qingdao University from January 2000 to December 2019 and who were followed until December 2020 were retrospectively analyzed. Clinical data and laboratory indexes were collected, and cut-off values for inflammatory markers were determined using median values. The Cox proportional hazard model was used to analyze the prognostic value of the markers through univariate and multivariate survival analysis. Results: All 253 patients met the inclusion criteria, and 102 (42.0%) patients had liver metastasis. The patients were divided into a high SII group and a low SII group, and the cut-off value was 533. In the multivariate analysis, high SII (HR = 2.151; Conclusions: A high level of SII is an independent risk factor for short overall survival of patients with metastatic and unresectable PC. Patients with a high level of the inflammatory markers SII, PLR, and NLR, may be more prone to early liver metastasis.
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