Evidence map›Paper›PMID 36111211›Full record

ArticleThe breast journal2022

Hospital Rurality and Gene Expression Profiling for Early-Stage Breast Cancer among Iowa Residents (2010-2018).

Danielle Riley, Mary Charlton, Elizabeth A Chrischilles, Ingrid M Lizarraga, Sneha Phadke, Brian J Smith, Adam Skibbe, Charles F Lynch

Abstract read
In one paragraph

Article in The breast journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Danielle RileyDepartment of Epidemiology, College of Public Health, University of Iowa, Iowa City, Iowa, USA.ORCID 0000-0002-9048-3936
Mary CharltonDepartment of Epidemiology, College of Public Health, University of Iowa, Iowa City, Iowa, USA.ORCID 0000-0003-2409-1018
Elizabeth A ChrischillesDepartment of Epidemiology, College of Public Health, University of Iowa, Iowa City, Iowa, USA.ORCID 0000-0002-1843-1955
Ingrid M LizarragaDepartment of Surgery, University of Iowa Hospitals and Clinics, Iowa, Iowa City, USA.ORCID 0000-0001-9376-1746
Sneha PhadkeDepartment of Internal Medicine-Hematology, Oncology and Blood and Marrow Transplantation, University of Iowa Hospitals and Clinics, Iowa, Iowa City, USA.ORCID 0000-0002-9829-1066
Brian J SmithHolden Comprehensive Cancer Center, University of Iowa, Iowa, Iowa City, USA.ORCID 0000-0003-1250-1710
Adam SkibbeDepartment of Geographical and Sustainability Sciences, College of Liberal Arts and Sciences, University of Iowa, Iowa, Iowa City, USA.ORCID 0000-0002-9862-3921
Charles F LynchDepartment of Epidemiology, College of Public Health, University of Iowa, Iowa City, Iowa, USA.ORCID 0000-0002-9542-6439

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Douglas Robert Spitz · 2000 to 2026
$70.0M
Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Brandi Janssen · 1990 to 2026
$40.5M
NCI NIH HHS HHSN261201000032CNCI NIH HHS HHSN261201300020CNCI NIH HHS HHSN261201300020INCI NIH HHS HHSN261201800020CNCI NIH HHS P30 CA086862NIEHS NIH HHS P30 ES005605
6 · The paper itself

Abstract

Objective: Given the challenges rural cancer patients face in accessing cancer care as well as the slower diffusion and adoption of new medical technologies among rural providers, the aim of our study was to examine trends in gene expression profiling (GEP) testing and evaluate the association between hospital rurality and receipt of GEP testing. Methods: Data from the Iowa Cancer Registry (ICR) were used to identify women with newly diagnosed, histologically confirmed breast cancer from 2010 through 2018 who met eligibility criteria for GEP testing. Patients were allocated to the hospitals where their most definitive surgical treatment was received, and Rural-Urban Commuting Area codes were used to categorize hospitals into urban ( Results: Of 6,726 patients eligible for GEP test use, 46% ( Conclusions: GEP testing continues to be underutilized, especially among those treated at small rural hospitals. Targeted interventions aimed at increasing rates of GEP testing to ensure the appropriate use of adjuvant chemotherapy may improve health outcomes and lower treatment-related costs.

Indexed as

Breast NeoplasmsChemotherapy, AdjuvantFemaleGene Expression ProfilingHospitalsHumansIowa

Identifiers

PMID36111211
PMCPMC9448596

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.