Evidence map›Paper›PMID 36111149›Full record

ArticleFrontiers in physiology2022

Long-term improvement by ozone treatment in chronic pain secondary to chemotherapy-induced peripheral neuropathy: A preliminary report.

Bernardino Clavo, Delvys Rodríguez-Abreu, Saray Galván, Mario Federico, Gregorio Martínez-Sánchez, Yolanda Ramallo-Fariña, Carla Antonelli, Gretel Benítez, Dolores Rey-Baltar, Ignacio J Jorge and 2 more

5 registry-linked trialsOpen access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04299893 phase2 / phase3recruitingnot on this map

Effectiveness and Cost-effectiveness of Ozone Therapy in Patients With Pain Secondary to Chemotherapy-induced Peripheral Neuropathy. Randomized, Triple-blind Clinical Trial (O3NPIQ)

TypeinterventionalSponsorBernardino Clavo, MD, PhDRan2020 to 2027Enrolled42ConditionsChemotherapy-induced Peripheral Neuropathy, Pain, Neuropathic, Pain SyndromeArmsOzone, Oxygen
NCT06706544 phase2 / phase3recruitingnot on this mapstarted 2025, after this paper: background citation

Effectiveness and Cost-effectiveness of Ozone Treatment in Patients With Paresthesia (Numbness, Tingling) Secondary to Chemotherapy-induced Peripheral Neuropathy. Randomized, Triple-blind Clinical Trial (OzoParQT)

TypeinterventionalSponsorBernardino Clavo, MD, PhDRan2025 to 2030Enrolled42ConditionsChemotherapy Induced Peripheral Neuropathy (CIPN), Paresthesia, Numbness, TinglingArmsOzone therapy, Oxygen (placebo)
NCT06799351 phase2 / phase3recruitingnot on this mapstarted 2025, after this paper: background citation

Evaluation of the Gut Microbiome Profiles in Patients with Chemotherapy-induced Peripheral Neuropathy Treated in the Randomized Clinical Trial with Ozone OzoParQT (NCT06706544).

TypeinterventionalSponsorBernardino Clavo, MD, PhDRan2025 to 2030Enrolled42ConditionsChemotherapy Induced Peripheral Neuropathy (CIPN), Paresthesia, Numbness, TinglingArmsOzone therapy, Oxygen (placebo)
NCT06816095 recruitingnot on this mapstarted 2025, after this paper: background citation

Gene and Molecular Pathway Characterization of the Response to Ozone Treatment in Gynecological Tumor Patients With Chronic Pelvic Pain Secondary to Radio-chemotherapy

TypeobservationalSponsorBernardino Clavo, MD, PhDRan2025 to 2027Enrolled40ConditionsChronic Pelvic Pain Syndrome (CPPS), Radiation-Induced Disorder, Radiotherapy Side Effects, Side Effect of Chemotherapy
NCT07325851 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Prospective and Observational Study of Patients Referred to the Chronic Pain Unit for Palliative Treatment With Ozone Therapy Between 2026 and 2029. Prospective Study EPOOzo-2.

Typeobservational_patient_registrySponsorBernardino Clavo, MD, PhDRan2026 to 2030Enrolled120ConditionsChemotherapy-Induced Peripheral Neuropathy, Radiation Toxicity, Chronic Pain, Delayed Wound HealingArmsOzone Therapy
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 2 countries.

Bernardino ClavoResearch Unit, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Spain.
Delvys Rodríguez-AbreuMedical Oncology Department, Complejo Hospitalario Universitario Insular Materno-Infantil de Gran Canaria, Las Palmas de Gran Canaria, Spain.
Saray GalvánMedical Oncology Department, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Spain.
Mario FedericoRadiation Oncology Department, Hospital Universitario Dr. Negrín, Las Palmas de Gran Canaria, Spain.
Gregorio Martínez-SánchezScientific Advisor, Freelance, Ancona, Italy.
Yolanda Ramallo-FariñaFundación Canaria Instituto de Investigación Sanitaria de Canarias (FIISC), Las Palmas de Gran Canaria, Spain.
Carla AntonelliMedical Oncology Department, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Spain.
Gretel BenítezMedical Oncology Department, Complejo Hospitalario Universitario Insular Materno-Infantil de Gran Canaria, Las Palmas de Gran Canaria, Spain.
Dolores Rey-BaltarRadiation Oncology Department, Hospital Universitario Dr. Negrín, Las Palmas de Gran Canaria, Spain.
Ignacio J JorgeChronic Pain Unit, Dr. Negrín University Hospital, Las Palmas de Gran Canaria, Spain.
Francisco Rodríguez-EsparragónResearch Unit, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Spain.
Pedro Serrano-AguilarResearch Network on Health Services in Chronic Diseases (REDISSEC), Instituto de Salud Carlos III, Madrid, Spain.
Hospital Universitario de Gran Canaria Doctor Negrín · ESHospital Universitario Insular de Gran Canaria · ESInstitute for Research in Biomedicine · ESOspedali Riuniti di Ancona · ITRed de Investigación en Actividades Preventivas y Promoción de la Salud · ESSistema Nacional de SaludUniversidad de La Laguna · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

antioxidantscancer survivorshipcancer therapy-induced side effectschemotherapy-induced peripheral neuropathyneuropathic painoxidative stressozone therapypain

Identifiers

PMID36111149
PMCPMC9468657
OpenAlexW4293548316

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.