Evidence map›Paper›PMID 36110842›Full record

ArticleFrontiers in immunology2022

An optimized Factor H-Fc fusion protein against multidrug-resistant

Jutamas Shaughnessy, Aleyo Chabeda, Y Tran, Bo Zheng, Nancy Nowak, Carolynn Steffens, Rosane B DeOliveira, Sunita Gulati, Lisa A Lewis, James Maclean and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 14 citations in OpenAlex.

  1. C4BP occludes the non-opsonic interaction ofInfection and immunity · 2026
    Article
  2. Review
  3. Review
  4. C4BP occludes the non-opsonic interaction ofbioRxiv : the preprint server for biology · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Mechanisms by which Factor H protectsFrontiers in immunology · 2024
    Article
  11. Article
  12. Recent advances onSynthetic and systems biotechnology · 2023
    Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Jutamas ShaughnessyDivision of Infectious Diseases and Immunology, University of Massachusetts Chan Medical School, Worcester, MA, United States.
Aleyo ChabedaDivision of Infectious Diseases and Immunology, University of Massachusetts Chan Medical School, Worcester, MA, United States.
Y TranPlanet Biotechnology, Inc., Hayward, CA, United States.
Bo ZhengDivision of Infectious Diseases and Immunology, University of Massachusetts Chan Medical School, Worcester, MA, United States.
Nancy NowakDivision of Infectious Diseases and Immunology, University of Massachusetts Chan Medical School, Worcester, MA, United States.
Carolynn SteffensDivision of Infectious Diseases and Immunology, University of Massachusetts Chan Medical School, Worcester, MA, United States.
Rosane B DeOliveiraDivision of Infectious Diseases and Immunology, University of Massachusetts Chan Medical School, Worcester, MA, United States.
Sunita GulatiDivision of Infectious Diseases and Immunology, University of Massachusetts Chan Medical School, Worcester, MA, United States.
Lisa A LewisDivision of Infectious Diseases and Immunology, University of Massachusetts Chan Medical School, Worcester, MA, United States.
James MacleanPlanet Biotechnology, Inc., Hayward, CA, United States.
John A MossOak Crest Institute of Science, Monrovia, CA, United States.
Keith L WycoffPlanet Biotechnology, Inc., Hayward, CA, United States.
Sanjay RamDivision of Infectious Diseases and Immunology, University of Massachusetts Chan Medical School, Worcester, MA, United States.
University of Massachusetts Chan Medical School · USPlanet Biotechnology (United States) · USOak Crest Institute of Science · US

Funding

Novel immunotherapeutics against multidrug-resistant Neisseria gonorrhoeaR01AI132296 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI RAM, SANJAY, RICE, PETER A. · 2017 to 2021
$5.5M
Sialic acid analogs against multidrug-resistant gonorrheaR01AI160247 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI MOSS, JOHN A, RAM, SANJAY · 2021 to 2025
$5.1M
An immunotherapeutic to prevent gonorrheaR44AI147930 · NIAID · PLANET BIOTECHNOLOGY, INC. · PI RAM, SANJAY, WYCOFF, KEITH · 2019 to 2021
$2.0M
NIAID NIH HHS R01 AI132296NIAID NIH HHS R01 AI160247NIAID NIH HHS R44 AI147930
6 · The paper itself

Abstract

Novel therapeutics against the global threat of multidrug-resistant

Indexed as

GonorrheaNeisseria gonorrhoeaeAnimalsComplement Factor HComplement System ProteinsDisease Models, AnimalFemaleHumansImmunoglobulin GMiceRecombinant Fusion ProteinsComplement Factor HComplement System ProteinsImmunoglobulin GRecombinant Fusion Proteinscomplementfactor HFc fusion proteingonorrheaimmunotherapeuticNeisseria gonorrhoeaeNicotiana benthamiana

Identifiers

PMID36110842
PMCPMC9468773
OpenAlexW4293589930

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.