Trial reportAnaesthesia2022
Ease and comfort of pre-oxygenation with high-flow nasal oxygen cannulae vs. facemask: a randomised controlled trial.
Trial report in Anaesthesia, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effect of high-flow nasal oxygen therapy on perioperative hypoxemia in children: a systematic review and meta-analysis.BMC anesthesiology · 2025Pooled it
- Oxygenation during the apnoeic phase preceding intubation in adults in prehospital, emergency department, intensive care and operating theatre environments.The Cochrane database of systematic reviews · 2023Pooled it
- Effect of transnasal humidified rapid insufflation ventilator exchange on early postoperative atelectasis in patients undergoing prolonged non-intubated anesthesia: a randomized clinical trial.BMC anesthesiology · 2026Trial
- Preoxygenation with high-flow nasal oxygen at various flow rates in elective surgical patients: a prospective, randomised, single-blind clinical trial.British journal of anaesthesia · 2026Trial
- Transnasal Humidified Rapid-Insufflation Ventilatory Exchange versus Oropharyngeal Airway-Assisted Face-Mask Ventilation for Gastric Insufflation During Induction of General Anesthesia in Patients at High Risk for Obstructive Sleep Apnea.Therapeutics and clinical risk management · 2026Trial
- Apnoeic oxygenation with high-flow nasal oxygen in adult patients undergoing endoscopic pharyngolaryngeal surgery: a clinical review.European journal of anaesthesiology and intensive care · 2026Review
- Preoxygenation with high-flow nasal oxygen versus conventional techniques using anatomical face mask in patients undergoing exploratory laparotomy: A randomised comparative study.Indian journal of anaesthesia · 2026Article
- Application of high-flow nasal oxygen during anesthesia induction for frame-based stereoelectroencephalography: a randomized controlled non-inferiority trial.Perioperative medicine (London, England) · 2025Article
- Article
- High-flow nasal cannula oxygen therapy versus non-invasive ventilation in healthy respiratory physicians: a non-randomized study.Frontiers in medicine · 2024Article
- Preoxygenation with standard facemask combining apnoeic oxygenation using high flow nasal cannula versuss standard facemask alone in patients with and without obesity: the OPTIMASK international study.Annals of intensive care · 2023Article
- High-flow nasal therapy: a game-changer in anesthesia and perioperative medicine?Brazilian journal of anesthesiology (Elsevier)Article
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Authors and funding
12 authors.
Funding
Abstract
The Difficult Airway Society recommends that all patients should be pre-oxygenated before the induction of general anaesthesia, but this may not always be easy or comfortable and anaesthesia may often be induced without full pre-oxygenation. We tested the hypothesis that high-flow nasal oxygen cannulae would be easier and more comfortable than facemasks for pre-oxygenation. We randomly allocated 199 patients undergoing elective surgery aged ≥ 10 years to pre-oxygenation using either high-flow nasal oxygen or facemask. Ease and comfort were assessed by anaesthetists and patients on 10-cm visual analogue scale and six-point smiley face scale, respectively. Secondary endpoints included end-tidal oxygen fraction after securing a definitive airway and time to secure an airway. A mean difference (95%CI) between groups in ratings of -0.76 (-1.25 to -0.27) cm for ease of use (p = 0.003) and -0.45 (-0.75 to -0.13) points for comfort (p = 0.006), both favoured high-flow nasal oxygen. A mean difference (95%CI) between groups in end-tidal oxygen fraction of 3.89% (2.41-5.37%) after securing a definitive airway also favoured high-flow nasal oxygen (p < 0.001). There was no significant difference between groups in the number of patients with hypoxaemia (S
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