Evidence map›Paper›PMID 36109772›Full record

ArticleBorderline personality disorder and emotion dysregulation2022

Identifying moderating factors during the preschool period in the development of borderline personality disorder: a prospective longitudinal analysis.

Kiran Boone, Alecia C Vogel, Rebecca Tillman, Amanda J Wright, Deanna M Barch, Joan L Luby, Diana J Whalen

Abstract read
In one paragraph

Article in Borderline personality disorder and emotion dysregulation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

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0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

7 authors.

Kiran BooneDepartment of Psychology, Washington University in St. Louis, St. Louis, MO, USA.
Alecia C VogelDepartment of Psychiatry, Washington University School of Medicine in St. Louis, 4444 Forest Park, Suite 2100, St. Louis, MO, 63108, USA.
Rebecca TillmanDepartment of Psychiatry, Washington University School of Medicine in St. Louis, 4444 Forest Park, Suite 2100, St. Louis, MO, 63108, USA.
Amanda J WrightDepartment of Psychology, Washington University in St. Louis, St. Louis, MO, USA.
Deanna M BarchDepartment of Psychology, Washington University in St. Louis, St. Louis, MO, USA.
Joan L LubyDepartment of Psychiatry, Washington University School of Medicine in St. Louis, 4444 Forest Park, Suite 2100, St. Louis, MO, 63108, USA.
Diana J WhalenDepartment of Psychiatry, Washington University School of Medicine in St. Louis, 4444 Forest Park, Suite 2100, St. Louis, MO, 63108, USA. diana.whalen@wustl.edu.

Funding

NEUROIMAGING IN EARLY ONSET DEPRESSION: LONGITUDINAL ASSESSMENT OF BRAIN CHANGESR01MH090786 · NIMH · WASHINGTON UNIVERSITY · PI GILBERT, KIRSTEN, WHALEN, DIANA J · 2010 to 2025
$10.4M
Influence of Physical Activity on Daily Positive Affect & Affective Neural Activity in PreschoolersK23MH118426 · NIMH · WASHINGTON UNIVERSITY · PI WHALEN, DIANA J · 2018 to 2022
$879k
NIMH NIH HHS K23 MH118426NIMH NIH HHS R01 5R01MH090786NIMH NIH HHS R01 MH090786
6 · The paper itself

Abstract

backgroundDespite a growing literature detailing early childhood risk factors for borderline personality disorder (BPD), few studies have examined moderating factors that might mitigate or exacerbate the effects of those risk factors. The current study examined whether three preschool-age characteristics-impulsivity, emotional lability, and initiative-taking-moderated the relationship between known preschool-age risk factors and adolescent BPD symptoms.

methodsWe performed multilevel modeling analyses in a sample (n = 151) from the Preschool Depression Study, a prospective longitudinal study with assessments from preschool through adolescence. Preschool risk factors included adverse childhood experiences, internalizing symptoms, and externalizing symptoms measured with parent clinical interviews. Preschool moderating factors were assessed via parent report and observational coding of temperament and behavior. The Borderline Personality Features Scale for Children measured BPD symptoms in adolescence.

resultsWe found that observed initiative-taking moderated the relationship between preschool internalizing symptoms and adolescent BPD symptoms (b = 0.57, p = .011) and moderated the relationship between preschool externalizing symptoms and adolescent BPD symptoms (b = 1.42, p = .013). Greater initiative-taking was associated with lower BPD risk for children with high internalizing or externalizing symptoms. Conversely, for children with low internalizing or externalizing symptoms, greater initiative-taking was associated with increased BPD risk.

conclusionsWe identify a potential moderating factor in BPD development, offer novel targets for screening and intervention, and provide a framework for using early childhood observational assessments in BPD research. Our findings suggest the need for future research on early moderating factors in BPD development, which could inform early childhood interventions targeting those factors to mitigate the effects of potentially less malleable risk factors.

Indexed as

Borderline personality disorderDevelopmental psychopathologyModerating factorsObservational codingResilience

Identifiers

PMID36109772
PMCPMC9479250

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.