Evidence map›Paper›PMID 36109730›Full record

ArticleBMC pediatrics2022

Blood pressure in children with sickle cell disease is higher than in the general pediatric population.

Juan C Kupferman, Janet E Rosenbaum, Marc B Lande, Stella Stabouli, Yongsheng Wang, Daniella Forman, Dimitrios I Zafeiriou, Steven G Pavlakis

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Juan C KupfermanDepartment of Pediatrics, Maimonides Medical Center, 977 48th street, Brooklyn, NY, 11219, USA. jkupferman@maimonidesmed.org.
Janet E RosenbaumSchool of Public Health, SUNY Downstate Health Sciences University, Brooklyn, NY, USA.
Marc B LandeDepartment of Pediatrics, University of Rochester, Rochester, NY, USA.
Stella Stabouli1st Department of Pediatrics, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Yongsheng WangSchool of Public Health, SUNY Downstate Health Sciences University, Brooklyn, NY, USA.
Daniella FormanSchool of Public Health, SUNY Downstate Health Sciences University, Brooklyn, NY, USA.
Dimitrios I Zafeiriou1st Department of Pediatrics, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Steven G PavlakisDepartment of Pediatrics, Maimonides Medical Center, 977 48th street, Brooklyn, NY, 11219, USA.
SUNY Downstate Health Sciences University · USAristotle University of Thessaloniki · GRMaimonides Medical Center · USUniversity of Rochester · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSickle cell disease (SCD) is associated with an increased risk of cardiovascular disease that may be due to a variety of possible risk factors, including abnormal blood pressure. Blood pressure (BP) of children and adolescents with SCD has been reported to be lower compared to the BP of the general pediatric population.

methodsTo confirm this prior observation, we compared reference BP values for children with SCD with reference BP values of the general pediatric population. We hypothesized that children with SCD do not have lower BPs than children without SCD.

resultsSystolic BP differed for both males and females, over the different age groups between pediatric subjects with and without SCD. Systolic BP was higher in children with SCD, in both obese and non-obese populations. Diastolic BP did not differ between the groups.

conclusionsOur analysis demonstrated that systolic BP values are indeed higher in children with SCD than in the general pediatric population. This finding is consistent with the most recent literature showing abnormal BP patterns in the SCD pediatric population utilizing 24-hour BP monitoring devices. This is an important step for recognizing abnormal BP as a risk factor for cardio- and neurovascular events in SCD.

Indexed as

Anemia, Sickle CellCardiovascular DiseasesAdolescentBlood PressureChildFemaleHumansMaleObesityRisk FactorsChildhoodHypertensionPediatric hematology/oncologyPediatricsSickle cell AnemiaSystolic

Identifiers

PMID36109730
PMCPMC9476310
OpenAlexW4296031721

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.