Trial reportBMC geriatrics2022
Sensory and motor correlates of frailty: dissociation between frailty phenotype and frailty index.
Trial report in BMC geriatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03666039 (Reversing Maladaptive Reorganization in Frail Brains), which is not on this map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Reversing Maladaptive Reorganization in Frail Brains: Sensorimotor Training, Brain Plasticity and the Role of Brain-derived Neurotrophic Factor
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- The impact of the number of remaining teeth on the risk of frailty: a meta-analysis.Odontology · 2026Pooled it
- Trial
- Beyond bone density: toward an integrated bone- muscle-function framework for fragility fracture prevention.Frontiers in medicine · 2026Article
- Neuromotor frailty phenotype and fall risk in geriatrics with knee osteoarthritis: a cross-sectional analysis of physical therapy performance and psychometric outcomes.Frontiers in medicine · 2026Article
- Age-related changes in hand function - it's not just about muscle strength.Frontiers in human neuroscience · 2026Review
- Comparison of the Frailty Phenotype and the Korean Version of the FRAIL Scale.Healthcare (Basel, Switzerland) · 2025Article
- Association between Visual, Hearing and Dual Sensory Impairment and the Frailty Syndrome.Aging and disease · 2025Article
- Effects of multicomponent exercise nursing intervention in elderly stroke patients with frailty: a randomized controlled trial.Frontiers in medicine · 2024Article
- Risk factors for postoperative delirium in frail elderly patients undergoing on-pump cardiac surgery and development of a prediction model-a prospective observational study.Frontiers in cardiovascular medicine · 2024Article
- Kinect-based objective assessment for early frailty identification in patients with Parkinson's disease.Aging clinical and experimental research · 2023Article
- Discordance in Frailty Measures in Old Community Dwelling People with Multimorbidity - A Cross-Sectional Study.Clinical interventions in aging · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFrailty has been associated with a decline in sensory and motor function. However, given that different frailty measures were shown to overlap but also differ in their diagnostic properties, sensory and motor correlates of frailty might be different depending on the operationalization of frailty. Our objective was to identify sensory and motor determinants of frailty and compare the results between frailty phenotype (FP) and frailty index (FI).
methodsData from 44 pre-frail and frail subjects aged 65 and above were used. Frailty was measured using the FP and the FI. Sensory function in the visual, auditory, and tactile domain was assessed using visual acuity, absolute hearing threshold and mechanical detection threshold. Upper extremity motor performance was evaluated by the Purdue Pegboard Test and the Short Physical Performance Battery was used to assess lower extremity motor function. Multiple logistic regression models were employed to determine associations of sensory and motor function with frailty vs. pre-frailty for both frailty measures.
resultsThe frailty measures were moderately correlated (0.497, p ≤ 0.01) and had a Kappa agreement of 0.467 (p = 0.002). Using the FP, frailty was significantly associated with reduced upper extremity motor function only (OR = 0.50, 95% CI 0.29-0.87, p = 0.014). Frailty as assessed by the FI was significantly related to higher hearing thresholds (OR = 1.21, 95% CI 1.02-1.43, p = 0.027) and reduced lower extremity performance (OR = 0.32, 95% CI 0.13-0.77, p = 0.012).
conclusionFrailty is related to reduced performance in measures of sensory and motor function. However, traditional measures of frailty might be differentially sensitive to capture sensory and motor decline, possibly contributing to the much-observed discordance between the diagnostic instruments. This should be taken into account by researchers and clinicians when planning and evaluating therapeutic interventions for frailty.
trial registrationClinicalTrials.gov NCT03666039 . Registered 11 September 2018 - Retrospectively registered.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.