Evidence map›Paper›PMID 36109647›Full record

ArticleNature chemical biology2023

Hydropersulfides inhibit lipid peroxidation and ferroptosis by scavenging radicals.

Uladzimir Barayeu, Danny Schilling, Mohammad Eid, Thamara Nishida Xavier da Silva, Lisa Schlicker, Nikolina Mitreska, Christopher Zapp, Frauke Gräter, Aubry K Miller, Reinhard Kappl and 3 more

Open access · hybridAbstract read
In one paragraph

Article in Nature chemical biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 120 papers.

0numbers the graph read from it
0cells of the map it votes in
120citing papers in PubMed
27.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

120 citing papers in PubMed, 219 citations in OpenAlex.

  1. HIV-1 gp120-induced lysosomal stress responses are controlled by TRPML1 redox sensors.Redox report : communications in free radical research · 2026
    Article
  2. Ferroptosis in liver biology and diseases.Hepatology communications · 2026
    Review
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  13. CoQExperimental & molecular medicine · 2026
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60 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Uladzimir BarayeuDivision of Redox Regulation, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID http://orcid.org/0000-0001-8426-166X
Danny Schilling *Division of Redox Regulation, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Mohammad Eid *Division of Redox Regulation, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Thamara Nishida Xavier da SilvaRudolf-Virchow-Zentrum - Center for Integrative and Translational Bioimaging, University of Würzburg, Würzburg, Germany.
Lisa SchlickerDivision of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Nikolina MitreskaDepartment of Biophysics, Faculty of Medicine, Center for Integrative Physiology and Molecular Medicine (CIPMM), Saarland University, Homburg, Germany.
Christopher ZappMolecular Biomechanics, Heidelberg Institute for Theoretical Studies (HITS), Heidelberg, Germany.
Frauke GräterMolecular Biomechanics, Heidelberg Institute for Theoretical Studies (HITS), Heidelberg, Germany.ORCID http://orcid.org/0000-0003-2891-3381
Aubry K MillerResearch Group Cancer Drug Development, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID http://orcid.org/0000-0002-1761-4143
Reinhard KapplDepartment of Biophysics, Faculty of Medicine, Center for Integrative Physiology and Molecular Medicine (CIPMM), Saarland University, Homburg, Germany.
Almut SchulzeDivision of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany.
José Pedro Friedmann AngeliRudolf-Virchow-Zentrum - Center for Integrative and Translational Bioimaging, University of Würzburg, Würzburg, Germany.ORCID http://orcid.org/0000-0001-7706-1379
Tobias P DickDivision of Redox Regulation, German Cancer Research Center (DKFZ), Heidelberg, Germany. t.dick@dkfz.de.ORCID http://orcid.org/0000-0003-1367-973X
German Cancer Research Center · DESaarland University · DEUniversity of Würzburg · DEHeidelberg Institute for Theoretical Studies · DEHeidelberg University · DE

Funding

European Research Council 101002812European Research Council 742039
6 · The paper itself

Abstract

Ferroptosis is a type of cell death caused by radical-driven lipid peroxidation, leading to membrane damage and rupture. Here we show that enzymatically produced sulfane sulfur (S

Indexed as

FerroptosisCell DeathFree RadicalsLipid PeroxidationSulfurFree RadicalsSulfur

Identifiers

PMID36109647
PMCPMC7613997
OpenAlexW4295951576

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.