SynthesisClinical rheumatology2022
A systematic review and meta-analysis of the hyperuricemia risk from certain metals.
Synthesis in Clinical rheumatology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- Prevalence of hyperuricemia among patients with non-communicable diseases in Ethiopia: a systematic review and meta-analysis.Cardiovascular diabetology. Endocrinology reports · 2026Review
- The link between dietary inflammation and hyperuricemia: what is the mediating role of insulin resistance and abdominal obesity?Nutrition & metabolism · 2026Article
- Selenium predominance in heavy metal mixtures is associated with hyperuricemia in Chinese adults: the role of insulin resistance.Frontiers in public health · 2026Article
- Molecular basis of the urate transporter URAT1 inhibition by gout drugs.Nature communications · 2025Article
- Protective Effects of a Polyherbal Mixture on Intestinal Injury via the NF-κB Signaling Pathway and Gut Microbiota Modulation in Hyperuricemic Mice.Foods (Basel, Switzerland) · 2025Article
- Estimation of Hair Toxic and Essential Trace Element and Mineral Profiles of Patients with Chronic Gout.Biological trace element research · 2025Article
- Potential pharmacological effect of Quercetin Phytosome™ in the management of hyperuricemia: results from real-life clinical studies.Frontiers in nutrition · 2025Article
- Molecular basis of the urate transporter URAT1 inhibition by gout drugs.bioRxiv : the preprint server for biology · 2024Article
- Hyperuricemia and its related diseases: mechanisms and advances in therapy.Signal transduction and targeted therapy · 2024Review
- Association between serum carotenoids and hyperuricemia: a cross-sectional study based on NHANES 2001-2006.Frontiers in nutrition · 2024Article
- Associations between blood essential metal mixture and serum uric acid: a cross-sectional study.Frontiers in public health · 2023Article
- A cross-sectional study on the association between dietary inflammatory index and hyperuricemia based on NHANES 2005-2018.Frontiers in nutrition · 2023Article
- Recent advances in the application of ionomics in metabolic diseases.Frontiers in nutrition · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The relationship between exposure to certain metals and the risk of hyperuricemia (HUA) has biological plausibility, yet prior studies have presented inconsistent findings. We aim to clarify the relationship between exposure to certain metals and HUA using a systematic review and meta-analysis approach. We searched the Web of Science, Embase, MEDLINE, Pubmed, Corchrane and China National Knowledge Infrastructure databases from inception through December, 2021 in order to identify studies that assessed the relationships between metals and the risk of HUA. Data were pooled by random-effects models and expressed as pooled odds ratios (OR) and 95% confidence intervals (CIs). The risk of bias was assessed using a tool from Agency for Healthcare Research and Quality (AHRQ). Twenty eligible articles (nineteen cross-sectional studies and one cohort) were included in our analysis, involving 63,283 participants in total. The studies showed that arsenic (pooled OR = 1.702, 95% CI: 1.44, 2.011; n = 6, I
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Registered trials
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