Evidence map›Paper›PMID 36109465›Full record

ReviewOphthalmology and therapy2022

Effects of Tafluprost on Ocular Blood Flow.

Xinyue Zhang, Xiaoyu Zhou, Yang Zhao, Xiang Yang, Dengming Zhou, Baihua Chen, Xuanchu Duan

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Ophthalmology and therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Xinyue ZhangChangsha Aier Eye Hospital, Changsha, Hunan, People's Republic of China.
Xiaoyu ZhouChangsha Aier Eye Hospital, Changsha, Hunan, People's Republic of China.
Yang ZhaoChangsha Aier Eye Hospital, Changsha, Hunan, People's Republic of China.
Xiang YangChangsha Aier Eye Hospital, Changsha, Hunan, People's Republic of China.
Dengming ZhouThe Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Baihua ChenThe Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Xuanchu DuanChangsha Aier Eye Hospital, Changsha, Hunan, People's Republic of China. duanxchu@csu.edu.cn.ORCID http://orcid.org/0000-0002-3148-1703
Central South University · CNHe Eye Hospital · CN

Funding

the Hunan Province research and development plan funding projects in key areas 2020SK2133 to XDthe National Natural Science Foundation of China 81970801 to XDthe Natural Science Foundation of Hunan Province, China 2019JJ40001 to XDthe Science and Technology Foundation of Aier Eye Hospital Group, China AM1906D2 to XDthe Science and Technology Foundation of Aier Eye Hospital Group, China AR1906D1the Science and Technology Foundation of Changsha, Hunan, China kh1801229 to XD
6 · The paper itself

Abstract

Increasing evidence indicates that improving ocular blood flow (OBF) can be a therapeutic direction for glaucoma therapy. Tafluprost, a prostaglandin analogue which lowers the intraocular pressure (IOP), has been shown to improve OBF in animals and humans. Several animal experiments showed that topical tafluprost significantly increased optic nerve head and retinal blood flow. Clinical trials also showed a beneficial effect of tafluprost on optic nerve head and macula blood flow, and a good ocular pulse amplitude-lowering effect. But, there are still a few conflicting results. Overall, tafluprost seems to have a beneficial effect on OBF, and the positive effect is probably independent from its IOP-lowering effect, which also is expected to improve OBF. Moreover, reducing the intracellular free Ca

Indexed as

GlaucomaMicrocirculationOcular blood flowProstaglandin analoguesTafluprost

Identifiers

PMID36109465
PMCPMC9587142
OpenAlexW4296028412

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.