Evidence map›Paper›PMID 36109390›Full record

GuidelineEuropean journal of pediatrics2022

Guidelines for the prevention and management of children and adolescents with COVID-19.

Enmei Liu, Rosalind Louise Smyth, Qinyuan Li, Amir Qaseem, Ivan D Florez, Joseph L Mathew, Yasser Sami Amer, Janne Estill, Quan Lu, Zhou Fu and 38 more

Open access · bronzeAbstract readPractice Guideline
PubMed Full text at PMC Publisher
In one paragraph

Guideline in European journal of pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
3.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Observational
  5. Remdesivir: treatment of COVID-19 in special populations.Naunyn-Schmiedeberg's archives of pharmacology · 2024
    Review
  6. Article
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

48 authors at 20 institutions in 16 countries.

Enmei Liu *Department of Respiratory Medicine Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing, China.
Rosalind Louise Smyth *UCL Great Ormond St Institute of Child Health, London, UK.
Qinyuan Li *Department of Respiratory Medicine Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing, China.
Amir QaseemClinical Policy and Center for Evidence Reviews, American College of Physicians, Philadelphia, USA.
Ivan D FlorezSchool of Rehabilitation Science, McMaster University, Hamilton, ON, Canada.
Joseph L MathewAdvanced Pediatrics Centre, PGIMER Chandigarh, Chandigarh, India.
Yasser Sami AmerResearch Chair for Evidence-Based Health Care and Knowledge Translation, King Saud University, Riyadh, Saudi Arabia.
Janne EstillInstitute of Global Health, University of Geneva, Geneva, Switzerland.
Quan LuShanghai Children's Hospital Affiliated to Shanghai Jiaotong University, Shanghai, China.
Zhou FuDepartment of Respiratory Medicine Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing, China.
Xiaoxia LuDepartment of Respiratory Medicine, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Edwin Shih-Yen ChanCentre for Quantitative Medicine, Office of Clinical Sciences, Duke-National University of Singapore Medical School, Singapore, Singapore.
Jürgen SchwarzeChildren's Research Network and Department of Child Life and Health, Centre for Inflammation Research, The University of Edinburgh, Edinburgh, UK.
Gary Wing-Kin WongDepartment of Pediatrics, The Chinese University of Hong Kong, Hong Kong, China.
Toshio FukuokaEmergency and Critical Care Center, the Department of General Medicine, Department of Research and Medical Education at Kurashiki Central Hospital, Kurashiki, Japan.
Hyeong Sik AhnDepartment of Preventive Medicine, Korea University, Seoul, South Korea.
Myeong Soo LeeClinical Medicine Division, Korea Institute of Oriental Medicine, Daejeon, South Korea.
Detty NurdiatiCochrane Indonesia, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.
Bin CaoDepartment of Pulmonary and Critical Care Medicine, National Center for Respiratory Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, China-Japan Friendship Hospital, Beijing, China.
Wenwei TuDepartment of Pediatrics & Adolescent Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China.
Yuan QianCapital Institute of Pediatrics, Beijing, China.
Shunying ZhaoBeijing Children's Hospital, Beijing, China.
Xiaoyan DongShanghai Children's Hospital Affiliated to Shanghai Jiaotong University, Shanghai, China.
Xiaoping LuoDepartment of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Zhimin ChenDepartment of Pulmonology, Children's Hospital Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
Guobao LiNational Clinical Research Center for Infectious Disease, Shenzhen, China.
Xiaobo ZhangChildren's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Xiaodong ZhaoDepartment of Pediatric Research Institute, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.
Hongmei XuDepartment of Infection Diseases Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing, China.
Feng XuDepartment of Critical Care Medicine Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing, China.
Yuan ShiDepartment of Neonatology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing, China.
Ruiqiu ZhaoDepartment of Infection Diseases Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing, China.
Yao ZhaoNational Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Infection and Immunity, Children's Hospital of Chongqing Medical University, Chongqing, China.
Junqiang LeiDepartment of Radiology, the First Hospital of Lanzhou University, Lanzhou, China.
Xianlan ZhengDepartment of Nursing, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Children's Hospital of Chongqing Medical University, Chongqing, China.
Mengshu WangDepartment of Radiology, the First Hospital of Lanzhou University, Lanzhou, China.
Shu YangChengdu University of TCM, Chengdu, China.
Xixi FengChengdu Medical College, Chengdu, China.
Liqun WuShenzhen Health Development Research Center, Shenzhen, China.
Zhihui HeChongqing Ninth People's Hospital, Chongqing, China.
Shihui LiuBeijing Jishuitan Hospital, Beijing, China.
Qi WangDepartment of Health Research Methods, Evidence & Impact (HEI), McMaster University, Hamilton, Canada.
Yang SongIberoamerican Cochrane Centre-Biomedical Research Institute Sant Pau (IIB Sant Pau), Barcelona, Spain.
Zhengxiu LuoDepartment of Respiratory Medicine Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing, China.
Qi ZhouResearch Unit of Evidence-Based Evaluation and Guidelines, Chinese Academy of Medical Sciences (2021RU017), School of Basic Medical Sciences, Lanzhou University, Lanzhou, China.
Gordon GuyattDepartment of Health Research Methods, Evidence & Impact (HEI), McMaster University, Hamilton, Canada.
Yaolong ChenResearch Unit of Evidence-Based Evaluation and Guidelines, Chinese Academy of Medical Sciences (2021RU017), School of Basic Medical Sciences, Lanzhou University, Lanzhou, China. chevidence@lzu.edu.cn.ORCID http://orcid.org/0000-0002-9841-5233
Qiu LiDepartment of Nephrology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing, China. liqiu_21@126.com.
Children's Hospital of Chongqing Medical University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNChina International Science and Technology Cooperation · CNFirst Hospital of Lanzhou University · CNImpact · CAShanghai Children's Hospital · CNAmerican College of Physicians · USBeijing Children’s Hospital · CNCapital Institute of Pediatrics · CNCentre for Inflammation Research · GBChengdu Medical College · CNChengdu University · CNChildren's Hospital of Fudan University · CNChildren's Hospital of Zhejiang University · CNChinese University of Hong Kong · HKDevelopment Research Center · CNGreat Ormond Street Hospital · GBIberoamerican Cochrane Centre · ESKing Saud Medical City · SAKorea University · KR

Funding

Fundamental Research Funds for the Central Universities lzujbky-2021-ey13National Clinical Research Center for Child Health and Disorders NCRCCHD-2020-EP-01
6 · The paper itself

Abstract

Children are the future of the world, but their health and future are facing great uncertainty because of the coronavirus disease 2019 (COVID-19) pandemic. In order to improve the management of children with COVID-19, an international, multidisciplinary panel of experts developed a rapid advice guideline at the beginning of the outbreak of COVID-19 in 2020. After publishing the first version of the rapid advice guideline, the panel has updated the guideline by including additional stakeholders in the panel and a comprehensive search of the latest evidence. All recommendations were supported by systematic reviews and graded using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system. Expert judgment was used to develop good practice statements supplementary to the graded evidence-based recommendations. The updated guideline comprises nine recommendations and one good practice statement. It focuses on the key recommendations pertinent to the following issues: identification of prognostic factors for death or pediatric intensive care unit admission; the use of remdesivir, systemic glucocorticoids and antipyretics, intravenous immunoglobulin (IVIG) for multisystem inflammatory syndrome in children, and high-flow oxygen by nasal cannula or non-invasive ventilation for acute hypoxemic respiratory failure; breastfeeding; vaccination; and the management of pediatric mental health.

conclusionThis updated evidence-based guideline intends to provide clinicians, pediatricians, patients and other stakeholders with evidence-based recommendations for the prevention and management of COVID-19 in children and adolescents. Larger studies with longer follow-up to determine the effectiveness and safety of systemic glucocorticoids, IVIG, noninvasive ventilation, and the vaccines for COVID-19 in children and adolescents are encouraged. WHAT IS KNOWN: • Several clinical practice guidelines for children with COVID-19 have been developed, but only few of them have been recently updated. • We developed an evidence-based guideline at the beginning of the COVID-19 outbreak and have now updated it based on the results of a comprehensive search of the latest evidence. WHAT IS NEW: • The updated guideline provides key recommendations pertinent to the following issues: identification of prognostic factors for death or pediatric intensive care unit admission; the use of remdesivir, systemic glucocorticoids and antipyretics, intravenous immunoglobulin for multisystem inflammatory syndrome in children, and high-flow oxygen by nasal cannula or non-invasive ventilation for acute hypoxemic respiratory failure; breastfeeding; vaccination; and the management of pediatric mental health.

Indexed as

AntipyreticsCOVID-19Respiratory InsufficiencyAdolescentChildCOVID-19 VaccinesHumansImmunoglobulins, IntravenousOxygenSystemic Inflammatory Response SyndromeAntipyreticsCOVID-19 VaccinesImmunoglobulins, IntravenousOxygenChildrenCOVID-19GuidelinesManagementPreventionSARS-CoV-2

Identifiers

PMID36109390
PMCPMC9483317
OpenAlexW4296036529

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.