Evidence map›Paper›PMID 36109004›Full record

ArticleClinical immunology (Orlando, Fla.)2022

RNA-seq characterization of histamine-releasing mast cells as potential therapeutic target of osteoarthritis.

Xiaoyi Zhao, Shady Younis, Hui Shi, Shu Hu, Amin Zia, Heidi H Wong, Eileen E Elliott, Tiffany Chang, Michelle S Bloom, Wei Zhang and 6 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical immunology (Orlando, Fla.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 26 citations in OpenAlex.

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  7. Identification of telomere-related diagnostic markers in osteoarthritis based on bioinformatics analysis and machine learning.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2025
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  13. Advances in clinical application of HZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Xiaoyi ZhaoVA Palo Alto Health Care System, Palo Alto, CA 94304, USA; Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Joint Surgery, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, China.
Shady YounisVA Palo Alto Health Care System, Palo Alto, CA 94304, USA; Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Hui ShiVA Palo Alto Health Care System, Palo Alto, CA 94304, USA; Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Shu HuVA Palo Alto Health Care System, Palo Alto, CA 94304, USA; Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Amin ZiaVA Palo Alto Health Care System, Palo Alto, CA 94304, USA; Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Heidi H WongVA Palo Alto Health Care System, Palo Alto, CA 94304, USA; Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Eileen E ElliottVA Palo Alto Health Care System, Palo Alto, CA 94304, USA; Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Tiffany ChangVA Palo Alto Health Care System, Palo Alto, CA 94304, USA; Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Michelle S BloomVA Palo Alto Health Care System, Palo Alto, CA 94304, USA; Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Wei ZhangVA Palo Alto Health Care System, Palo Alto, CA 94304, USA; Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Xiangyang LiuVA Palo Alto Health Care System, Palo Alto, CA 94304, USA; Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Tobias Volker LanzVA Palo Alto Health Care System, Palo Alto, CA 94304, USA; Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Orr SharpeVA Palo Alto Health Care System, Palo Alto, CA 94304, USA; Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Zelda Z LoveVA Palo Alto Health Care System, Palo Alto, CA 94304, USA; Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Qian WangVA Palo Alto Health Care System, Palo Alto, CA 94304, USA; Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: qian957@stanford.edu.
William H RobinsonVA Palo Alto Health Care System, Palo Alto, CA 94304, USA; Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: w.robinson@stanford.edu.
VA Palo Alto Health Care System · US

Funding

BLRD VA I01 BX004713CSRD VA I01 CX002523RRD VA I01 RX002689
6 · The paper itself

Abstract

objectiveMast cells in the osteoarthritis (OA) synovium correlate with disease severity. This study aimed to further elucidate the role of mast cells in OA by RNA-Seq analysis and pharmacological blockade of the activity of histamine, a key mast cell mediator, in murine OA.

methodsWe examined OA synovial tissues and fluids by flow cytometry, immunostaining, single-cell and bulk RNA-Seq, qPCR, and ELISA. Cetirizine, a histamine H1 receptor (H

resultsFlow cytometry and immunohistology analysis of OA synovial cells revealed KIT

conclusionBased on differential expression of prototypical and distinct mast cell markers, human OA joints can be stratified into mast cell-high, -medium, and -low synovial tissue pathotypes. Pharmacologic blockade of histamine activity holds the potential to improve OA disease outcome.

Indexed as

Arthritis, RheumatoidOsteoarthritisAnimalsCetirizineHistamineHumansInterleukin-1 Receptor-Like 1 ProteinMast CellsMiceReceptors, Histamine H1RNA-SeqSynovial MembraneTryptasesCetirizineHistamineIl1rl1 protein, mouseInterleukin-1 Receptor-Like 1 ProteinReceptors, Histamine H1TryptasesHistamineHistamine H(1) receptor (H(1)R)Mast cellOsteoarthritisRNA-Seq

Identifiers

PMID36109004
PMCPMC10752578
OpenAlexW4295413721

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.