ArticleThe Journal of infection2022
Risk factors for Crimean-Congo Haemorrhagic Fever (CCHF) virus exposure in farming communities in Uganda.
Article in The Journal of infection, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 43 citations in OpenAlex.
- A One Health investigation of a Crimean-Congo Hemorrhagic fever outbreak reveals high seropositivity in livestock in Lyantonde District, Uganda, 2024.One health (Amsterdam, Netherlands) · 2026Article
- Tick-host-virus triad in Crimean-Congo hemorrhagic fever transmission: global patterns across vector and reservoir species.Veterinary research communications · 2026Review
- Crimean-Congo Hemorrhagic Fever Virus in Africa: Epidemiological Trends, Transmission Ecology, Hotspot Heterogeneity, and Preparedness Challenges-A Narrative Review.Tropical medicine and infectious disease · 2026Review
- Seroprevalence of Crimean-Congo Hemorrhagic Fever Virus Infection in Humans and Domestic Ruminants, Democratic Republic of the Congo.Emerging infectious diseases · 2026Article
- Investigating the Sudan virus outbreak in Uganda through the deployment of a mobile laboratory.BMC infectious diseases · 2026Article
- Phylogenetic insights into the transmission dynamics of arthropod-borne viruses.Nature reviews. Genetics · 2026Review
- Longitudinal seroprevalence of Crimean-Congo hemorrhagic fever virus in Southern Uganda.Emerging microbes & infections · 2025Article
- Serologic evidence of crimean-congo hemorrhagic fever virus exposure among livestock and farmers in the Democratic Republic of the Congo.PLoS neglected tropical diseases · 2025Article
- Factors associated with knowledge, attitudes, and practices of mixed crop-livestock farmers on Crimean-Congo hemorrhagic fever (CCHF) and other zoonoses in Burkina Faso.One health (Amsterdam, Netherlands) · 2025Article
- Uncovering the viral aetiology of undiagnosed acute febrile illness in Uganda using metagenomic sequencing.Nature communications · 2025Article
- Seroprevalence and risk factors for Crimean-Congo hemorrhagic fever virus exposure among febrile patients in northern Tanzania.Tropical medicine & international health : TM & IH · 2025Article
- Towards a 'people and nature' paradigm for biodiversity and infectious disease.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- Prevalence of Crimean-Congo Haemorrhagic Fever virus and Ganjam virus among livestock & ticks in Wayanad, Kerala.Veterinary research communications · 2024Article
- Crimean-Congo haemorrhagic fever outbreak in Northern Senegal in 2022: Prevalence of the virus in livestock and ticks, associated risk factors and epidemiological implications.Zoonoses and public health · 2024Article
- Control strategies for emerging infectious diseases: Crimean-Congo hemorrhagic fever management.Health science reports · 2024Article
- Viruses of free-roaming and hunting dogs in Uganda show elevated prevalence, richness and abundance across a gradient of contact with wildlife.The Journal of general virology · 2024Article
- Epidemiologic Survey of Crimean-Congo Hemorrhagic Fever Virus in Suids, Spain.Emerging infectious diseases · 2024Article
- Serological Evidence of Crimean-Congo Haemorrhagic Fever in Livestock in the Omaheke Region of Namibia.Microorganisms · 2024Article
- Investigating Crimean-Congo haemorrhagic fever virus seropositivity in camels and human behavioural risks in an abattoir in Nigeria.Epidemiology and infection · 2024Article
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Authors and funding
21 authors at 7 institutions in 2 countries.
Funding
Abstract
backgroundCrimean-Congo Haemorrhagic Fever (CCHF) is an emerging human-health threat causing sporadic outbreaks in livestock farming communities. However, the full extent and the risks associated with exposure of such communities has not previously been well-described.
methodsWe collected blood samples from 800 humans, 666 cattle, 549 goats and 32 dogs in districts within and outside Ugandan cattle corridor in a cross-sectional survey, and tested for CCHFV-specific IgG antibodies using Enzyme-Linked Immunosorbent Assays. Sociodemographic and epidemiological data were recorded using structured questionnaire. Ticks were collected to identify circulating nairoviruses by metagenomic sequencing.
resultsCCHFV seropositivity was in 221/800 (27·6%) in humans, 612/666 (91·8%) in cattle, 413/549 (75·2%) in goats and 18/32 (56·2%) in dogs. Human seropositivity was associated with livestock farming (AOR=5·68, p<0·0001), age (AOR=2·99, p=0·002) and collecting/eating engorged ticks (AOR=2·13, p=0·004). In animals, seropositivity was higher in cattle versus goats (AOR=2·58, p<0·0001), female sex (AOR=2·13, p=0·002) and heavy tick infestation (>50 ticks: AOR=3·52, p=0·004). CCHFV was identified in multiple tick pools of Rhipicephalus appendiculatus.
interpretationThe very high CCHF seropositivity especially among livestock farmers and multiple regional risk factors associated exposures, including collecting/eating engorged ticks previously unrecognised, highlights need for further surveillance and sensitisation and control policies against the disease.
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