Evidence map›Paper›PMID 36108766›Full record

ArticleArchives of physical medicine and rehabilitation2023

Longitudinal Associations Between Falls and Risk of Gait Decline: Results From the Central Control of Mobility and Aging Study.

Oshadi Jayakody, Helena M Blumen, Emmeline Ayers, Joe Verghese

Open access · greenAbstract read
In one paragraph

Article in Archives of physical medicine and rehabilitation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Oshadi JayakodyDepartment of Medicine, Albert Einstein College of Medicine, Bronx, NY.
Helena M BlumenDepartment of Medicine, Albert Einstein College of Medicine, Bronx, NY; Department of Neurology, Albert Einstein College of Medicine, Bronx, NY.
Emmeline AyersDepartment of Neurology, Albert Einstein College of Medicine, Bronx, NY.
Joe VergheseDepartment of Medicine, Albert Einstein College of Medicine, Bronx, NY; Department of Neurology, Albert Einstein College of Medicine, Bronx, NY. Electronic address: joe.verghese@einsteinmed.edu.
Albert Einstein College of Medicine · US

Funding

The biological underpinnings of Motoric Cognitive Risk syndrome: a multi-center studyR01AG057548 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI VERGHESE, JOE · 2020 to 2024
$8.0M
Non-Invasive Home Neurostimulation for Mild to Moderate Alzheimer's Disease: Double-Blind, Sham Controlled Randomized Clinical TrialR01AG068167 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI KNOTKOVA, HELENA, VERGHESE, JOE · 2020 to 2024
$6.2M
Trajectories and modifiable risk factors of brain, gait, and cognitive decline in aging and pre-dementiaR01AG062659 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI BLUMEN, HELENA M · 2020 to 2024
$3.8M
Biological and neural mechanisms of fallsR01AG044007 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI VERGHESE, JOE · 2013 to 2017
$3.5M
Central Control of Mobility in AgingR01AG036921 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI HOLTZER, ROEE · 2011 to 2015
$3.3M
5-Cog Battery to improve detection of cognitive impairment and dementiaUG3NS105565 · NINDS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI VERGHESE, JOE · 2017 to 2018
$1.4M
NIA NIH HHS R01 AG036921NIA NIH HHS R01 AG044007NIA NIH HHS R01 AG057548NIA NIH HHS R01 AG062659NIA NIH HHS R01 AG068167NINDS NIH HHS UG3 NS105565
6 · The paper itself

Abstract

objectiveTo examine whether falls are associated with longitudinal changes in different gait domains and onset of clinical gait abnormalities.

designLongitudinal study.

settingGeneral community.

participantsAmbulatory older adults free of dementia (N=428; mean age, 77.8±6.4 years).

interventionsNot applicable.

main outcome measuresGait was assessed with a computerized walkway. Pace, rhythm, and variability (outcome measures) were derived from individual gait measures, using principal component analysis. Clinical gait abnormalities (neurologic, nonneurologic, mixed) were visually assessed by clinicians. Linear mixed-effects models were used to examine the associations between falls (the exposure variable coded as none, single, and multiple) and changes in gait domains. Multinomial logistic regression was used to examine associations between falls and the onset of clinical gait abnormalities. Models were adjusted for sex, education, age, body mass index, number of comorbidities, gait speed at the first follow-up, and time between the last fall and the first follow-up gait assessment.

resultsPace declined while rhythm and variability increased at a faster rate (P<.05) among 32 participants with multiple falls in the first year of follow-up compared with 299 participants with no falls. Risk for clinical gait abnormalities between those with no falls, a single fall, or multiple falls was not different.

conclusionsMultiple falls predict future gait decline in multiple domains in aging. Interventions to prevent gait decline after multiple falls should be investigated.

Indexed as

AgingGaitAgedAged, 80 and overHumansLongitudinal StudiesProspective StudiesWalking SpeedAccidental fallsLongitudinal studiesRehabilitationWalking speed

Identifiers

PMID36108766
PMCPMC9898168
OpenAlexW4295537205

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.