ArticleAnimal bioscience2023
Comparison of metabolites in rumen fluid, urine, and feces of dairy cow from subacute ruminal acidosis model measured by proton nuclear magnetic resonance spectroscopy.
Article in Animal bioscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 7 citations in OpenAlex.
- Subacute ruminal acidosis in high-producing dairy cows: an integrated diet-microbiota-epithelium-host framework for diagnosis and nutritional management.Journal of animal science and biotechnology · 2026Review
- Supplementation with willow containing condensed tannins shifted nitrogen excretion from urine to faeces in yearling ewes.Animal : an international journal of animal bioscience · 2025Article
- Rumen fermentation shifts and microbial dynamics in mid-lactating Holstein dairy cows experiencing heat stress and subsequent recovery periods.Animal bioscience · 2025Article
- Feed Efficiency and Growth Performance in Thai Beef Cattle Fed Cricket Meal as a Soybean Meal Replacement.Veterinary medicine international · 2025Article
- Comparison of Fecal Microbiota and Metabolites Between Captive and Grazing Male Reindeer.Animals : an open access journal from MDPI · 2024Article
- The Impact of Varying Pasture Levels on the Metabolomic Profile of Bovine Ruminal Fluid.Metabolites · 2024Article
- Blood and milk metabolites of Holstein dairy cattle for the development of objective indicators of a subacute ruminal acidosis.Animal bioscience · 2023Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveIn this study, metabolites that changed in the rumen fluid, urine and feces of dairy cows fed different feed ratios were investigated.
methodsEight Holstein cows were used in this study. Rumen fluid, urine, and feces were collected from the normal concentrate diet (NCD) (Italian ryegrass 80%: concentrate 20% in the total feed) and high concentrate diet (HCD) groups (20%: 80%) of dairy cows. Metabolite analysis was performed using proton nuclear magnetic resonance (NMR) identification, and statistical analysis was performed using Chenomx NMR software 8.4 and Metaboanalyst 4.0.
resultsThe two groups of rumen fluid and urine samples were separated, and samples from the same group were aggregated together. On the other hand, the feces samples were not separated and showed similar tendencies between the two groups. In total, 160, 177, and 188 metabolites were identified in the rumen fluid, urine, and feces, respectively. The differential metabolites with low and high concentrations were 15 and 49, 14 and 16, and 2 and 2 in the rumen fluid, urine, and feces samples, in the NCD group.
conclusionAs HCD is related to rumen microbial changes, research on different metabolites such as glucuronate, acetylsalicylate, histidine, and O-Acetylcarnitine, which are related to bacterial degradation and metabolism, will need to be carried out in future studies along with microbial analysis. In urine, the identified metabolites, such as gallate, syringate, and vanillate can provide insight into microbial, metabolic, and feed parameters that cause changes depending on the feed rate. Additionally, it is thought that they can be used as potential biomarkers for further research on subacute ruminal acidosis.
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