ArticleNature2022
Structures of α-synuclein filaments from human brains with Lewy pathology.
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In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 291 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
291citing papers in PubMed, 2 pooled it
52.4field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
291 citing papers in PubMed, 2 syntheses or guidelines pooled it, 454 citations in OpenAlex.
- Diagnostic biomarkers for α-synucleinopathies- state of the art and future developments: a systematic review.Molecular neurodegeneration · 2025Pooled it
- Cerebrospinal fluid and blood neurofilament light chain in Parkinson's disease and atypical parkinsonian syndromes: a systematic review and Bayesian network meta-analysis.Journal of neurology · 2025Pooled it
- Probing the Energy Landscape of α-Synuclein Amyloid Fibril Formation by Systematic K-to-Q Mutagenesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Cryo-EM structure of TGFBIp fibrils driven by a corneal dystrophy-linked mutation enables design of peptide inhibitors of aggregation.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Efficacy and Safety of Electroconvulsive Therapy for Dementia With Lewy Bodies, Its Prodromal Phase, and Parkinson's Disease Dementia: Eight Cases Encountered at Our Institution.Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2026Article
- Neuronal overexpression of Kcnn1 in A53T α-synuclein mice suppresses phospho-serine 129 α-synuclein formation and doubles survival time.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Review
- α-Synuclein strain homogeneity in multiple system atrophy subtypes.Brain pathology (Zurich, Switzerland) · 2026Article
- α-Synuclein blocks endoplasmic reticulum co-translational protein translocation early in Parkinson's disease.Nature communications · 2026Article
- Vaccines mimicking conformational epitopes on α-synuclein fibrils provide immunity to Parkinson's disease.Brain : a journal of neurology · 2026Article
- Inter-assay and Inter-site Performance of Alpha-Synuclein Seed Amplification Assays in Synucleinopathies: A Multicenter 2 × 2 Protocol Comparison.Neurology and therapy · 2026Article
- Progression of Motor and Cognitive Functions in Isolated REM Sleep Behavior Disorder: A 7-Year Prospective Matched Cohort Study.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Synthetic strategies for small molecule compounds for the treatment of Parkinson's disease: targeting α-synuclein.Molecular diversity · 2026Review
- Multiple system atrophy: cure and care.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- In Vitro-Prepared A30P Alpha-Synuclein Fibrils Adopt the Conserved and Disease-Relevant Greek Key Fold.The journal of physical chemistry. B · 2026Article
- Calcineurin/NFAT signaling in the temporal integration of Ca²⁺ stress in neurodegeneration.Cell death discovery · 2026Review
- Correlative ultrastructural mapping of Lewy pathology reveals regional diversity in Parkinson's and dementia with Lewy bodies.Acta neuropathologica · 2026Article
- α-Synuclein aggregation landscape from phase separation to neurotoxic intermediates.FEBS letters · 2026Review
- Lewy pathology largely absent in prefrontal cortices of Parkinson's disease patients undergoing deep brain stimulation.NPJ Parkinson's disease · 2026Article
- Small bites for big problems: stepwise aggregate degradation by autophagy.Biochemical Society transactions · 2026Review
231 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
20 authors at 8 institutions in 4 countries.
Yang YangMedical Research Council Laboratory of Molecular Biology, Cambridge, UK.ORCID http://orcid.org/0000-0003-2238-6437
Yang ShiMedical Research Council Laboratory of Molecular Biology, Cambridge, UK.ORCID http://orcid.org/0000-0003-1579-7561
Manuel SchweighauserMedical Research Council Laboratory of Molecular Biology, Cambridge, UK.ORCID http://orcid.org/0000-0002-1848-1610
Xianjun ZhangThermo Fisher Scientific, Eindhoven, The Netherlands.
Abhay KotechaThermo Fisher Scientific, Eindhoven, The Netherlands.ORCID http://orcid.org/0000-0002-4480-5439
Alexey G MurzinMedical Research Council Laboratory of Molecular Biology, Cambridge, UK.
Holly J GarringerDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID http://orcid.org/0000-0002-1899-7676
Patrick W CullinaneDepartment of Clinical and Movement Neurosciences, Queen Square Institute of Neurology, University College London, London, UK.
Yuko SaitoDepartment of Neuropathology, Metropolitan Institute of Gerontology, Tokyo, Japan.
Tatiana ForoudDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID http://orcid.org/0000-0002-5549-2212
Thomas T WarnerDepartment of Clinical and Movement Neurosciences, Queen Square Institute of Neurology, University College London, London, UK.ORCID http://orcid.org/0000-0001-6195-6995
Kazuko HasegawaDivision of Neurology, Sagamihara National Hospital, Sagamihara, Japan.
Ruben VidalDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Shigeo MurayamaMolecular Research Centre for Children's Mental Development, United School of Child Development, University of Osaka, Osaka, Japan.
Tamas ReveszQueen Square Brain Bank for Neurological Disorders, Institute of Neurology, University College London, London, UK.
Bernardino GhettiDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID http://orcid.org/0000-0002-1842-8019
Masato HasegawaDepartment of Brain and Neurosciences, Metropolitan Institute of Medical Science, Tokyo, Japan.ORCID http://orcid.org/0000-0001-7415-8159
Tammaryn LashleyQueen Square Brain Bank for Neurological Disorders, Institute of Neurology, University College London, London, UK.
Sjors H W ScheresMedical Research Council Laboratory of Molecular Biology, Cambridge, UK. scheres@mrc-lmb.cam.ac.uk.ORCID http://orcid.org/0000-0002-0462-6540
Michel GoedertMedical Research Council Laboratory of Molecular Biology, Cambridge, UK. mg@mrc-lmb.cam.ac.uk.ORCID http://orcid.org/0000-0002-5214-7886
MRC Laboratory of Molecular Biology · GBIndiana University School of MedicineKing's College London · GBNational Hospital for Neurology and Neurosurgery · GBThermo Fisher Scientific (Netherlands) · NLNational Sagamihara Hospital · JPTokyo Metropolitan Institute of Gerontology · JPTokyo Metropolitan Institute of Medical Science · JP
Funding
Research Education ComponentP30AG010133 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI SAYKIN, ANDREW J · 1991 to 2020
$37.3MResearch Education ComponentP30AG072976 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI ANDREW J SAYKIN · 2021 to 2026
$24.1MPARKINSON DISEASE COLLABORATIVE STUDY OF GENETIC LINKAGER01NS037167 · NINDS · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI FOROUD, TATIANA M. · 1998 to 2010
$11.7MAtomic models of human tau filaments and development of tau ligandsU01NS110437 · NINDS · INDIANA UNIVERSITY INDIANAPOLIS · PI GHETTI, BERNARDINO FRANCESCO, JIANG, WEN · 2018 to 2022
$3.5MStructural analysis of tau associated with parenchymal and vascular prion protein amyloidosisRF1AG071177 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI GHETTI, BERNARDINO FRANCESCO, JIANG, WEN · 2021 to 2021
$2.3MMedical Research Council MC_EX_MR/N50192X/1Medical Research Council MC_U105184291Medical Research Council MC_UP_A025_1013NIA NIH HHS P30 AG010133NIA NIH HHS P30 AG072976NIA NIH HHS RF1 AG071177NINDS NIH HHS R01 NS037167NINDS NIH HHS U01 NS110437Wellcome Trust
Abstract
Parkinson's disease (PD) is the most common movement disorder, with resting tremor, rigidity, bradykinesia and postural instability being major symptoms
Indexed as
alpha-SynucleinBrainBrain ChemistryCryoelectron MicroscopyLewy Body DiseaseDementiaHumansParkinson Diseasealpha-Synuclein
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.