Evidence map›Paper›PMID 36108605›Full record

ArticleBiofabrication2022

Biofabrication of 3D breast cancer models for dissecting the cytotoxic response of human T cells expressing engineered MAIT cell receptors.

Madhuri Dey, Myong Hwan Kim, Momoka Nagamine, Ece Karhan, Lina Kozhaya, Mikail Dogan, Derya Unutmaz, Ibrahim T Ozbolat

Open access · greenAbstract read
In one paragraph

Article in Biofabrication, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
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  5. 3D bioprinting innovations: a new frontier in breast cancer research.Medical oncology (Northwood, London, England) · 2025
    Review
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  7. Article
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  16. Mucosal-associated invariant T cells for cancer immunotherapy.Molecular therapy : the journal of the American Society of Gene Therapy · 2023
    Review
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Madhuri DeyDepartment of Chemistry, Penn State University, University Park, PA 16802, United States of America.
Myong Hwan KimThe Huck Institutes of the Life Sciences, Penn State University, University Park, PA 16802, United States of America.
Momoka NagamineDepartment of Chemistry, Penn State University, University Park, PA 16802, United States of America.
Ece KarhanThe Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, United States of America.
Lina KozhayaThe Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, United States of America.
Mikail DoganThe Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, United States of America.
Derya UnutmazThe Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, United States of America.
Ibrahim T OzbolatThe Huck Institutes of the Life Sciences, Penn State University, University Park, PA 16802, United States of America.ORCID 0000-0001-8328-4528
Jackson Laboratory · USPennsylvania State University · US

Funding

Immune-Cancer Cell Interactions in a 3D Bioprinted Tumor MicroenvironmentR21CA224422 · NCI · JACKSON LABORATORY · PI UNUTMAZ, DERYA · 2018 to 2019
$428k
NCI NIH HHS R21 CA224422
6 · The paper itself

Abstract

Immunotherapy has revolutionized cancer treatment with the advent of advanced cell engineering techniques aimed at targeted therapy with reduced systemic toxicity. However, understanding the underlying immune-cancer interactions require development of advanced three-dimensional (3D) models of human tissues. In this study, we fabricated 3D tumor models with increasing complexity to study the cytotoxic responses of CD8

Indexed as

Breast NeoplasmsMucosal-Associated Invariant T CellsCytokinesFemaleFibrinGranzymesHumansInterferon-gammaInterleukin-13LigandsMinor Histocompatibility AntigensReceptors, Antigen, T-CellT-LymphocytesTumor MicroenvironmentCytokinesFibrinGranzymesInterferon-gammaInterleukin-13LigandsMinor Histocompatibility AntigensReceptors, Antigen, T-Cell3D bioprinting3D tumor modelscancerimmunotherapyMAIT-MR1

Identifiers

PMID36108605
PMCPMC9556424
OpenAlexW4296036536

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.