Evidence map›Paper›PMID 36108310›Full record

Trial reportDiabetes technology & therapeutics2023

The Associations of Mean Glucose and Time in Range from Continuous Glucose Monitoring with HbA1c in Adults with Type 2 Diabetes.

Elizabeth Selvin, Dan Wang, Mary R Rooney, Justin Echouffo-Tcheugui, Michael Fang, Scott Zeger, Joseph Sartini, Olive Tang, Josef Coresh, R Nisha Aurora and 1 more

Registry-linked trialOpen access · greenAbstract readClinical Trial
In one paragraph

Trial report in Diabetes technology & therapeutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02454153 (Hyperglycemic Profiles in Obstructive Sleep Apnea), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02454153 nacompletednot on this map

Hyperglycemic Profiles in Obstructive Sleep Apnea: Effects of PAP Therapy

TypeinterventionalSponsorJohns Hopkins UniversityRan2014 to 2020Enrolled184ConditionsSleep Apnea, DiabetesArmsREMStar Positive Airway Pressure, LifeStyle Counseling
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Perspective of Continuous Glucose Monitoring-Based Interventions at the Various Stages of Type 2 Diabetes.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2024
    Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Elizabeth SelvinDepartment of Epidemiology and Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.ORCID 0000-0001-6923-7151
Dan WangDepartment of Epidemiology and Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Mary R RooneyDepartment of Epidemiology and Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Justin Echouffo-TcheuguiWelch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, Maryland, USA.
Michael FangDepartment of Epidemiology and Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Scott ZegerWelch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, Maryland, USA.
Joseph SartiniWelch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, Maryland, USA.
Olive TangDepartment of Epidemiology and Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Josef CoreshDepartment of Epidemiology and Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
R Nisha AuroraDepartment of Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
Naresh M PunjabiDivision of Pulmonary, Critical Care, and Sleep Medicine, University of Miami, Miller School of Medicine, Miami, Florida, USA.
Johns Hopkins University · USRutgers, The State University of New Jersey · USUniversity of Miami · US

Funding

CARDIOVASCULAR EPIDEMIOLOGY INSTITUTIONAL TRAININGT32HL007024 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Elizabeth Selvin · 1985 to 2026
$17.5M
Medical Scientist Training ProgramT32GM136577 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI ANDREA L COX · 2020 to 2026
$13.4M
Clinical relevance of glucose patterns in older adultsR01DK128837 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SELVIN, ELIZABETH · 2021 to 2024
$2.7M
Effects of the DASH diet on glucose patterns in adults with type 2 diabetesR01DK128900 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SELVIN, ELIZABETH · 2021 to 2025
$2.6M
Research and Mentoring in the Clinical Epidemiology of Type 2 DiabetesK24DK106414 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SELVIN, ELIZABETH · 2015 to 2019
$654k
NHLBI NIH HHS T32 HL007024NIDDK NIH HHS K24 DK106414NIDDK NIH HHS R01 DK128837NIDDK NIH HHS R01 DK128900NIGMS NIH HHS T32 GM136577
6 · The paper itself

Abstract

Associations of mean glucose and time in range (70-180 mg/dL) from continuous glucose monitoring (CGM) with HbA1c in adults with type 2 diabetes are not well characterized. We conducted a secondary analysis of 186 participants from the Hyperglycemic Profiles in Obstructive Sleep Apnea (HYPNOS) trial. Participants simultaneously wore Dexcom G4 and Abbott Libre Pro CGM sensors up to 4 weeks. Mean HbA1c was 7.7% (SD, 1.3). There were strong negative Pearson's correlations of HbA1c with CGM time in range (-0.79, Abbott; -0.81, Dexcom) and strong positive correlations with CGM mean glucose (Dexcom, 0.84; Abbott, 0.82). However, there were large differences in CGM mean glucose (±20 mg/dL) and time in range (±14%) at any given HbA1c value. Mean glucose and HbA1c are strongly correlated in type 2 diabetes patients not taking insulin but discordance is evident at the individual level. Clinicians should expect discordance and use HbA1c and CGM in a complementary manner. ClinicalTrials.gov Identifier: NCT02454153.

Indexed as

Diabetes Mellitus, Type 1Diabetes Mellitus, Type 2HypoglycemiaAdultBlood GlucoseBlood Glucose Self-MonitoringGlucoseGlycated HemoglobinHumansHypoglycemic AgentsBlood GlucoseGlucoseGlycated HemoglobinHypoglycemic AgentsContinuous glucose monitoringHbA1cMean glucoseType 2 diabetesVariability

Identifiers

PMID36108310
PMCPMC9810347
OpenAlexW4296039099

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.