ArticleAngewandte Chemie (International ed. in English)2022
Ruthenium(II)/Imidazolidine Carboxylic Acid-Catalyzed C-H Alkylation for Central and Axial Double Enantio-Induction.
Article in Angewandte Chemie (International ed. in English), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Electrochemical Enantioselective Ruthenium(II)-Catalyzed C-H Activations to Atropostable Indoles and Chiral Spiropyrazolones.Journal of the American Chemical Society · 2026Article
- Achiral benzoic acid appended helical polymers for the copper-catalyzed asymmetric Diels-Alder reaction and Michael addition with excellent enantioselectivity and recyclability.Chemical science · 2026Article
- SphereDiff-TS: Sphere Space Diffusion Modeling for Accurate 3D Transition State Geometry Prediction.ACS omega · 2026Article
- Ruthenium-Catalyzed CH Alkenylation of Trypanocidal Naphthoquinones: A Mechanistic Benchmarking Study.ChemistryOpen · 2026Article
- Enantiotopic-group-selective coupling for unified access to carbazole atropisomers as versatile chiral chromophores.Nature communications · 2025Article
- Three-Coordinate Iron(0) Complex-Catalyzed Regioselective C-H Alkylation of Indole Derivatives.Journal of the American Chemical Society · 2025Article
- Access to distal biaxial atropisomers by iridium catalyzed asymmetric C-H alkylation.Chemical science · 2024Article
- Pd-catalyzed asymmetric Larock reaction for the atroposelective synthesis of N─N chiral indoles.Science advances · 2024Article
- Iron-catalyzed stereoselective C-H alkylation for simultaneous construction of C-N axial and C-central chirality.Nature communications · 2024Article
- The crucial role of silver(I)-salts as additives in C-H activation reactions: overall analysis of their versatility and applicability.Chemical Society reviews · 2023Review
- Cobaltaelectro-Catalyzed C-H Annulation with Allenes for Atropochiral andACS catalysis · 2023Article
- Data-driven design of new chiral carboxylic acid for construction of indoles with C-central and C-N axial chirality via cobalt catalysis.Nature communications · 2023Article
- Ruthenium(II)/Imidazolidine Carboxylic Acid-Catalyzed C-H Alkylation for Central and Axial Double Enantio-Induction.Angewandte Chemie (International ed. in English) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Enantioselective C-H activation has surfaced as a transformative toolbox for the efficient assembly of chiral molecules. However, despite of major advances in rhodium and palladium catalysis, ruthenium(II)-catalyzed enantioselective C-H activation has thus far largely proven elusive. In contrast, we herein report on a ruthenium(II)-catalyzed highly regio-, diastereo- and enantioselective C-H alkylation. The key to success was represented by the identification of novel C2-symmetric chiral imidazolidine carboxylic acids (CICAs), which are easily accessible in a one-pot fashion, as highly effective chiral ligands. This ruthenium/CICA system enabled the efficient installation of central and axial chirality, and featured excellent branched to linear ratios with generally >20 : 1 dr and up to 98 : 2 er. Mechanistic studies by experiment and computation were carried out to understand the catalyst mode of action.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.