Evidence map›Paper›PMID 36108173›Full record

ArticleAmerican journal of respiratory cell and molecular biology2023

Epithelial Endoplasmic Reticulum Stress Enhances the Risk of Muc5b-associated Lung Fibrosis.

Evgenia Dobrinskikh, Corinne E Hennessy, Jonathan S Kurche, Eunjoo Kim, Alani M Estrella, Jonathan Cardwell, Ivana V Yang, David A Schwartz

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 25 citations in OpenAlex.

  1. Progenitor Resilience and the Early Onset of Chronic Lung Diseases: NHLBI workshop report.American journal of respiratory cell and molecular biology · 2026
    Article
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  10. Association of theFrontiers in genetics · 2025
    Article
  11. Review
  12. American journal of respiratory and critical care medicine · 2024
    Article
  13. AAmerican journal of respiratory cell and molecular biology · 2024
    Article
  14. Article
  15. Alveolar epithelial regeneration in the aging lung.The Journal of clinical investigation · 2023
    Review
  16. Review
  17. Review
  18. The Integrated Stress Response Links Muc5b to Pulmonary Fibrosis.American journal of respiratory cell and molecular biology · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Evgenia DobrinskikhDepartment of Medicine.ORCID 0000-0003-4595-2913
Corinne E HennessyDepartment of Medicine.ORCID 0000-0002-5398-4459
Jonathan S KurcheDepartment of Medicine.ORCID 0000-0002-4244-1870
Eunjoo KimDepartment of Medicine.ORCID 0000-0001-9238-0618
Alani M EstrellaRoy and Diana Vagelos College of Physicians and Surgeons, Columbia University Medical Center, New York, New York; and.ORCID 0000-0001-5447-6205
Jonathan CardwellDepartment of Medicine.
Ivana V YangDepartment of Medicine.ORCID 0000-0002-1018-489X
David A SchwartzDepartment of Medicine.ORCID 0000-0001-6743-8443
Colorado School of Public Health · USColumbia University Irving Medical Center · USPediatrics and Genetics · USUniversity of Colorado Anschutz Medical Campus · US

Funding

Targeting early events in MUC5B-driven lung injury and fibrosisP01HL162607 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI Ivana V Yang · 2023 to 2026
$12.4M
Preclinical Pulmonary Fibrosis, an opportune rare disease cohortUH3HL151865 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI SCHWARTZ, DAVID ALBERT · 2022 to 2025
$4.3M
Molecular Determinants of Usual Interstitial Pneumonia (UIP)R01HL158668 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI David Albert Schwartz, Ivana V Yang · 2022 to 2026
$3.5M
Genes and Transcripts that Interact with MUC5B in Pulmonary FibrosisR01HL149836 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI CLOUTHIER, DAVID E., SCHWARTZ, DAVID ALBERT · 2020 to 2023
$3.0M
The role of multiciliated cell dysfunction in pathogenesis of IPFF32HL154666 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI KIM, EUN JOO · 2020 to 2023
$177k
Role of Muc5b in Honeycomb Cyst FormationF32HL134243 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI KURCHE, JONATHAN SCOTT · 2017 to 2017
$72k
lncRNAs, Linking Genetic Susceptibility to Molecular Phenotype in IPFI01BX005295 · VA · VA EASTERN COLORADO HEALTH CARE SYSTEM · PI David Albert Schwartz · 2022 to 2026
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BLRD VA I01 BX005295NHLBI NIH HHS F32 HL134243NHLBI NIH HHS F32 HL154666NHLBI NIH HHS P01 HL162607NHLBI NIH HHS R01 HL149836NHLBI NIH HHS R01 HL158668NHLBI NIH HHS UH3 HL151865
6 · The paper itself

Abstract

The gain-of-function minor allele of the

Indexed as

Idiopathic Pulmonary FibrosisMucin-5BAnimalsBleomycinEndoplasmic Reticulum StressEukaryotic Initiation Factor-2BMiceBleomycinEukaryotic Initiation Factor-2BMuc5b protein, mouseMucin-5BAtf4 (activating transcription factor 4)ER stressidiopathic pulmonary fibrosisintegrated stress response inhibitorMuc5b (mucin 5Boligomeric mucus/gel-forming)

Identifiers

PMID36108173
PMCPMC9817917
OpenAlexW4296028650

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.