ArticleJMIR research protocols2022
Long-term Consequences of COVID-19 and the Pandemic: Protocol for a Web-Based, Longitudinal Observational Study (DEFEAT).
Article in JMIR research protocols, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- Trial
- Longitudinal observation of persistent Long COVID symptoms and health-related quality of life in an adult German cohort.BMC infectious diseases · 2026Observational
- Impact of post-exertional malaise frequency and fatigue in Long COVID patients on health-related quality of life.Health and quality of life outcomes · 2026Article
- App-based self-management program for people dealing with fatigue and trouble concentrating (DiEgO): protocol for participatory development, pilot testing, and qualitative process evaluation.Pilot and feasibility studies · 2026Article
- [Inflammatory rheumatic diseases in patients with post-COVID syndrome].Zeitschrift fur Rheumatologie · 2026Article
- Post-COVID fatigue disproportionately affects women: evidence from the DEFEAT Corona cohort.Frontiers in public health · 2026Article
- Childhood trauma and mental health outcomes in Post-COVID Syndrome: Results from a cross-sectional study in Germany.Brain, behavior, & immunity - health · 2025Article
- Evaluating the Feasibility, Acceptance, and Beneficial Effects of Online Occupational Therapy for Post-COVID-19 Condition: Protocol for a Randomized Controlled Trial (ErgoLoCo Study).JMIR research protocols · 2024Article
- How do people with long COVID utilize COVID-19 vaccination and rehabilitation services and what are their experiences with these services? results of a qualitative study with 48 participants from Germany.BMC public health · 2024Article
- Article
- "There is no one who helps you with it": experiences of people with long COVID regarding medical care, therapeutic measures, and barriers in the German healthcare system: results of a qualitative study with four focus groups.BMC health services research · 2023Article
- Amino acids, post-translational modifications, nitric oxide, and oxidative stress in serum and urine of long COVID and ex COVID human subjects.Amino acids · 2023Article
- Epidemiology, Symptomatology, and Risk Factors for Long COVID Symptoms: Population-Based, Multicenter Study.JMIR public health and surveillance · 2023Article
- Migrant healthcare workers during COVID-19: bringing an intersectional health system-related approach into pandemic protection. A German case study.Frontiers in public health · 2023Article
- How do long COVID patients perceive their current life situation and occupational perspective? Results of a qualitative interview study in Germany.Frontiers in public health · 2023Article
- Parenting and Gender as Impact Factors for Social Participation, Quality of Life, and Mental Health in Long COVID.Journal of primary care & community healthArticle
Corrections and comments
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Authors and funding
15 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWith population-wide vaccination availability, the global COVID-19 pandemic entered a new phase. Despite vaccination status, some people who were infected with SARS-CoV-2 experience long-term symptoms.
objectiveIn this study, we aim to characterize the long-term effects of SARS-CoV-2 infection and the pandemic. We also aim to build symptom clusters and determine risk factors for developing long COVID symptoms. Furthermore, we assess social participation and health-related quality of life in patients with long COVID and in the general population during a global pandemic.
methodsWith a mixed-methods, web-based approach, we aim to recruit 2000 people in Germany who are older than 18 years and can provide informed consent. In the quantitative arm of the study, we identify symptoms of and predictive factors for long COVID manifestations with cluster analysis and assess social participation during the pandemic with standardized questionnaires. The qualitative arm of the study uses individual interviews and focus group discussions to better understand the illness experience of persons who experience long COVID.
resultsRecruitment started in September 2021. Up until July 2022, we recruited approximately 4500 participants via our web-based database.
conclusionsThis study aims to build an innovative, patient-centered, web-based research platform appropriate for the pandemic by minimizing physical contact between study personnel and participants. All study activities are designed to better understand the long COVID syndrome, social participation during the pandemic, and the illness experiences of persons affected by long COVID.
trial registrationGerman Clinical Trial Registry DRKS00026007; https://tinyurl.com/yh282fkt. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/38718.
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